Efficacy of a novel tetracycline derivative, glycylcycline, against penicillin-resistant Streptococcus pneumoniae in a mouse model of pneumonia

Journal of Antimicrobial Chemotherapy

Volumn 46, Issue 4, 2000, Pages 629-631

  Murakami, Kenichiro ^a   Tateda, Kazuhiro ^a   Matsumoto, Tetsuya ^a   Miyazaki, Shuichi ^a   Yamaguchi, Keizo ^a  

^a TOHO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMPICILLIN; ERYTHROMYCIN; GLYCYLCYCLINE; MINOCYCLINE; NEW DRUG; PENICILLIN G; TETRACYCLINE; TETRACYCLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BACTERIAL COUNT; BACTERICIDAL ACTIVITY; COLONY FORMING UNIT; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG HALF LIFE; DRUG TISSUE LEVEL; FEMALE; IN VIVO STUDY; LUNG; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; PENICILLIN RESISTANCE; STREPTOCOCCUS PNEUMONIA; STREPTOCOCCUS PNEUMONIAE;

ANIMAL; ANTIBIOTICS, TETRACYCLINE; DISEASE MODELS, ANIMAL; FEMALE; LUNG; MICE; MICE, INBRED CBA; MICROBIAL SENSITIVITY TESTS; MINOCYCLINE; PENICILLIN G; PENICILLINS; PNEUMONIA, PNEUMOCOCCAL; STREPTOCOCCUS PNEUMONIAE; TETRACYCLINE;

EID: 0033785957     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/46.4.629     Document Type: Article

References (6)

1. In vitro activities of two glycylcyclines against gram-positive bacteria
2. Susceptibility of enterococci, methicillin-resistant Staphylococcus aureus and Streptococcus pneumoniae to the glycylcyclines
3. In vitro activities of two glycylcyclines
4. Establishment of a model of penicillin-resistant Streptococcus pneumoniae pneumonia in healthy CBA/J mice
5. Noncompromised penicillin-resistant pneumococcal pneumonia CBA/J mouse model and comparative efficacies of antibiotics in this model