Mobilisation of cadmium by meso- and racemic-2,3-dimercaptosuccinic acid (DMSA) in rats

Pharmacology and Toxicology

Volumn 87, Issue 4, 2000, Pages 179-181

  Blanuša, Maja ^a   Kostial, Krista ^a   Restek Samaržija, Nada ^b   Piasek, Martina ^a   Jones, Mark M ^c   Singh, Pramod K ^d  

^a INSTITUTE FOR MEDICAL RESEARCH AND OCCUPATIONAL HEALTH   (Croatia)

^b Roche Pharmaceuticals   (Croatia)

^c VANDERBILT UNIVERSITY   (United States)

^d Food Residue and Toxicology Laboratory   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CADMIUM 109; SUCCIMER;

ANIMAL EXPERIMENT; ARTICLE; CADMIUM POISONING; CHELATION; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; IN VIVO STUDY; ISOMERISM; KIDNEY; LIVER; NONHUMAN; PRIORITY JOURNAL; RADIOACTIVITY; RAT; WHOLE BODY COUNTING;

ANIMALIA;

EID: 0033783762     PISSN: 09019928     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0773.2000.d01-70.x     Document Type: Article

References (16)

1. Andersen, O.: Principles and recent developments in chelation treatment of metal intoxication. Chem. Rev. 1999, 99, 2683-2710.
2. Basinger, M. A., M. M. Jones & L. L. Shinobu: Structural requirements for chelate antidotes for acute cadmium intoxication. J. Inorg. Nucl. Chem. 1981, 43, 3039-3042.
3. Cantilena, L. R. Jr. & C. D. Klaassen: Comparison of the effectiveness of several chelators after single administration on the toxicity, excretion, and distribution of cadmium. Toxicol. Appl. Pharmacol. 1981, 58, 452-460.
4. Eybl, V., J. Sykora, J. Koutensky, D. Caisova, A. Schwartz & F. Mertl: Interaction of chelating agents with cadmium in mice and rats. Environ. Health Perspect. 1984, 54, 267-273.
5. Fang, X. J., F. M. Hua & Q. Fernando: Comparison of rac- and meso-2,3-dimercaptosuccinic acids for chelation of mercury and cadmium using chemical speciation models. Chem. Res. Toxicol. 1996, 9, 284-290.
6. Jones, M. M.: New developments in therapeutic chelating agents as antidotes for metal poisoning, Crit. Rev. Toxicol. 1991, 21, 209-233.
7. Jones, M. M. & M. G. Cherian: The search for chelate antagonists for chronic cadmium intoxication. Toxicology 1990, 62, 1-25.
8. Jones, M. M., P. K. Singh, G. R. Gale, L. M. Atkins & A. B. Smith: Esters of meso-dimercaptosuccinic acid as cadmium-mobilizing agents. Toxicol. Appl. Pharmacol. 1988, 95, 507-514.
9. Jones, M. M., P. K. Singh, G. R. Gale, A. B. Smith & L. M. Atkins: Cadmium mobilization in vivo by intraperitoneal or oral administration of monoalkyl esters of meso-2,3-dimercaptosuccinic acid in the mouse. Pharmacology & Toxicology 1992, 70, 336-343.
10. Jones, M. M., P. K. Singh, M. A. Basinger, G. R. Gale, A. B. Smith & W. R. Harris: Design of in vivo cadmium-mobilizing agents - synthesis and properties of monobenzyl meso-2,3-dimer-captosuccinate. Chem. Res. Toxicol. 1994a, 7, 367-373.
11. Jones, M. M., P. K. Singh, M. A. Basinger, G. R. Gale & A. B. Smith: Cadmium mobilization by monoaralkyl- and monoalkyl esters of meso-2,3-dimercaptosuccinic acid and by a dithiocarbamate. Pharmacology & Toxicology 1994b, 74, 76-83.
12. Jones, M. M., P. K. Singh, K. Kostial, M. Blanuša, M. Piasek & N. Restek-Samaržija: Comparative in vivo lead mobilisation of meso- and rac-2,3-dimercaptosuccinic acids in albino Wistar rats. Pharmacology & Toxicology 1997, 80, 182-186.
13. Kostial, K., N. Restek-Samaržija, M. Blanuša, M. Piasek, Lj. Prester, M. M. Jones & P. K. Singh: Racemic-2,3-dimercaptosuccinic acid for inorganic mercury mobilization in rats. J. Appl. Toxicol 1997, 17, 71-74.
14. Planas-Bohne, F: Chelate treatment in acute cadmium intoxication. Experientia 1980, 36, 1001-1002.
15. Singh, P. K., M. M. Jones, K. Kostial, M. Blanuša & M. Piasek: In vivo cadmium mobilization by three novel bis(carbodithioates). Chem. Res. Toxicol. 1996a, 9, 313-317.
16. Singh, P. K., M. M. Jones, K. Kostial, M. Blanuša, M. Piasek & N. Restek-Samaržija: meso-2,3-dimercaptosuccinic acid mono-N-alkylamides: Syntheses and biological activity as novel in vivo cadmium mobilizing agents. Chem. Res. Toxicol. 1996b, 9, 965-969.