Synthesis of N-methyl-4-pyridyl-1, 2, 3, 4-tetrahydroisoquinolines via a Pictet-Spengler cyclisation

Journal of Heterocyclic Chemistry

Volumn 37, Issue 4, 2000, Pages 767-771

  Prat, Laurence ^a   Levacher, Vincent ^a   Dupas, Georges ^a   Quéguiner, Guy ^a   Bourguignon, Jean ^a   Bureau, Ronan ^b   Daveu, Cyril ^b  

^a IRCOF   (France)

^b CENTRE D ETUDES ET DE RECHERCHE SUR LE MÉDICAMENT DE NORMANDIE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

N METHYL 4 (PYRID 2 YL) 1,2,3,4 TETRAHYDROISOQUINOLINE; N METHYL 4 (PYRID 3 YL) 1,2,3,4 TETRAHYDROISOQUINOLINE; N METHYL 4 (PYRID 4 YL) 1,2,3,4 TETRAHYDROISOQUINOLINE; SEROTONIN DERIVATIVE; TETRAHYDROISOQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL ANALYSIS; CHEMICAL REACTION; CHEMICAL STRUCTURE; CYCLIZATION; DRUG SYNTHESIS; STRUCTURE ANALYSIS;

EID: 0033782688     PISSN: 0022152X     EISSN: None     Source Type: Journal    
DOI: 10.1002/jhet.5570370417     Document Type: Article

References (16)

1. Serotonin receptors: Subtypes, functional responses and therapeutic relevance
2. Proteins: Structure, function and genetics
3. It is generally observed that the aromatic electrophilic substitution reaction, occuring during the Pictet-Spengler condensation, is well accomplished when the aromatic ring is electron rich