Immunologic effects of gliotoxin in rats: Mechanisms for prevention of autoimmune diabetes mellitus

Annals of Clinical and Laboratory Science

Volumn 30, Issue 4, 2000, Pages 366-378

  Liu, H ^a   Jackman, S ^a   Driscoll, H ^a   Larsen, B ^a  

^a DES MOINES UNIVERSITY   (United States)

Author keywords

Apoptosis; Autoimmunity; Diabetes mellitus; Mycotoxin; T lymphocytes

Indexed keywords

GLIOTOXIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; DIABETES MELLITUS; FEMALE; IMMUNOMODULATION; LYMPHOCYTE SUBPOPULATION; MALE; NATURAL KILLER CELL; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; RAT; T LYMPHOCYTE;

ADP RIBOSE TRANSFERASES; ANIMAL; ANTIGENS, CD5; APOPTOSIS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CONCANAVALIN A; DIABETES MELLITUS, INSULIN-DEPENDENT; FEMALE; FLOW CYTOMETRY; GLIOTOXIN; HISTOCOMPATIBILITY ANTIGENS CLASS II; IMMUNOSUPPRESSIVE AGENTS; IN SITU NICK-END LABELING; IN VITRO; KILLER CELLS, NATURAL; MALE; MEMBRANE GLYCOPROTEINS; RATS; RATS, INBRED BB; SPLEEN;

EID: 0033782256     PISSN: 00917370     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Effect of GT on development of diabetes mellitus in diabetes-prone BB/Wor rats
2. The effects of GT upon macrophage function
3. Immunosuppression in vitro by a metabolite of a pathogenic fungus
4. Autoimmune diabetes mellitus in the BB rat
5. Cyclosporin increases the rate and length of remissions in insulin-dependent diabetes of recent onset. Results of a multicenter double-blind trial
6. Clinical management of spontaneous diabetes mellitus in the BB rat
7. Exacerbation of invasive aspergillosis by the immunosuppressive fungal metabolite, GT
8. Suppressive effects of Aspergillus fumigatus culture filtrates on human alveolar macrophages and polymorphonuclear leucocytes
9. Investigation of the potential use of immunosuppressive agent GT in organ transplantation
10. + T cells
11. + T cell subsets are required for the transfer of diabetes in nonobese diabetic mice
12. Characterization of pancreatic islet cell infiltrates in NOD mice: Effect of cell transfer and transgene expression
13. - T-lymphocytes in T-lymphocyte-depleted NOD mice
14. + T cells from diabetic versus prediabetic NOD. NON-Thy-1a donors
15. + T cell-dependent
16. Transfer of autoimmune diabetes from diabetic NOD mice to NOD athymic nude mice: The roles of T cell subsets in the pathogenesis
17. Transfer of diabetes in the NON-scid mouse by CD4 T-cell clones. Differential requirement for CD8 T-cells
18. Abnormalities within CD4 and CD8 T lymphocyte subsets in type 1 (insulin-dependent) diabetes
19. Absence of the RT-6 T cell subset in diabetes-prone BB/W rats
20. The RT6 rat lymphocyte alloantigen circulates in soluble form
21. An RT6a gene is transcribed and translated in lymphopenic diabetes-prone BB rats
22. The expanding universe of T-cell subsets: Th 1, Th 2 and more
23. DNA fragmentation induced in macrophages by GT does not require protein synthesis and is preceded by raised inositol triphosphate levels
24. GT induces apoptosis in macrophages unrelated to its antiphagocytic properties
25. The immunomodulating agent GT causes genomic DNA fragmentation
26. Evidence that GT enhances lymphocyte activation and induces apoptosis by effects on cyclic AMP levels
27. Molecular and cellular mechanisms regulating T and B cell apoptosis through Fas/FasL interaction
28. Cellular uptake and release of the immunomodulating fungal toxin GT