Efficacy of dexfenfluramine in the treatment of alcohol dependence

Alcoholism: Clinical and Experimental Research

Volumn 24, Issue 10, 2000, Pages 1534-1541

  Romach, Myroslava K ^a   Sellers, Edward M ^a   Kaplan, Howard L ^a   Somer, Gail R ^a   Gomez Mancilla, Baltazar ^b  

^a SUNNYBROOK RESEARCH INSTITUTE   (Canada)

^b CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

Author keywords

Alcohol; Combination Therapy; Comorbidity; Dexfenfluramine; Serotonin

Indexed keywords

ALCOHOL; DEXFENFLURAMINE; FLUOXETINE; NALTREXONE; PLACEBO; SEROTONIN UPTAKE INHIBITOR;

ADULT; AGED; ALCOHOLISM; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; FATIGUE; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; NEUROTRANSMITTER RELEASE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SEROTONIN RELEASE; TREATMENT OUTCOME; XEROSTOMIA;

EID: 0033782170     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000374-200010000-00011     Document Type: Article

References (75)

1. A relapse prevention model for the treatment of alcoholics
2. Social drinking as a health and psychosocial risk factor. Anstie's limit revisited
3. Effect of citalopram on alcohol intake in heavy drinkers
4. An inventory for measuring clinical anxiety: Psychometric properties
5. Psychometric properties of the Beck Depression Inventory: Twenty-five years of evaluation
6. Differences between d-fenfluramine and d-norfenfluramine in serotonin presynaptic mechanisms
7. d-Fenfluramine suppresses the increased calorie and carbohydrate intakes and improves the mood of women with premenstrual depression
8. Effects of the total extract and fractions of Hypericum perforatum in animal assays for antidepressant activity
9. Hyperforin as a possible antidepressant component of hypericum extracts
10. Antidepressant activity of Hypericum perforatum and hyperforin: The neglected possibility
11. Fluoxetine in depressed alcoholics
12. In vitro receptor binding and enzyme inhibition by Hypericum perforatum extract
13. Sertraline with naltrexone versus naltrexone alone in the treatment of alcohol dependence
14. Pharmacological treatment of alcohol dependence. A review of the evidence
15. Effect of fluoxetine on alcohol consumption in male alcoholics
16. Comorbidity between DSM-IV alcohol use disorders and major depression: Results of a national survey
17. Prevalence of DSM-IV alcohol abuse and dependence
18. The assessment of anxiety states by rating
19. A rating scale for depression
20. The co-occurrence of alcoholism with other psychiatric disorders in the general population and its impact on treatment
21. Effects of drugs influencing 5-HT function on ethanol drinking and feeding behaviour in rats. Studies using a drinkometer system
22. Fenfluramine augmentation of serotonin reuptake blockade anti-obsessional treatment
23. Ritanserin in the treatment of alcohol dependence - A multi-center trial
24. A placebo-controlled, double-blind study of fluoxetine in severe alcohol dependence: Adjunctive pharmacotherapy during and after inpatient treatment
25. Alcoholism and major depression in women: A twin study of the causes of comorbidity
26. Implications of recent neuropsychopharmacologic research for understanding the etiology and development of alcoholism
27. Buspirone treatment of anxious alcoholics: A placebo-controlled trial
28. Placebo-controlled trial of fluoxetine as an adjunct to relapse prevention in alcoholics
29. A trial of fenfluramine in the treatment of chronic alcoholic patients
30. Opiate and 5-HT(2A) receptors in alcohol drinking: Preference in HAD rats is inhibited by combination treatment with naltrexone and amperozide
31. 3 receptor antagonists in the regulation of alcohol intake
32. Serotonin and alcohol intake, abuse and dependence: Clinical evidence
33. Advances in development of medications for alcoholism treatment
34. A placebo-controlled trial of buspirone in anxious inpatient alcoholics
35. Dexfenfluramine: A review of its pharmacological properties and therapeutic potential in obesity
36. Anorectic effect of fenfluramine isomers and metabolites: Relationship between brain levels and in vitro potencies on serotonergic mechanisms
37. Comorbidity for alcoholism and depression
38. Motivation and treatment goals
39. Effects of Hypericum extract (L1 160) in biochemical models of antidepressant activity
40. Fluoxetine differentially alters alcohol intake and other consummatory behaviours in problem drinkers
41. Zimelidine-induced variations in alcohol intake by non-depressed heavy drinkers
42. The serotonin uptake inhibitor citalopram attenuates ethanol intake
43. Differential effects of viqualine on alcohol intake and other consummatory behaviors
44. Treatment of seasonal depression with d-fenfluramine
45. Effects of Hypericum perforatum extract on alcohol intake in Marchigian Sardinian alcohol-preferring rats
46. Comorbidity of mental disorders with alcohol and other drug abuse. Results from the Epidemiologic Catchment Area (ECA) Study
47. Attenuation of alcohol intake by extract of Hypericum perforatum (St. John's wort) in two different strains of alcohol-preferring rats
48. The economic cost of alcohol abuse and alcohol dependence: 1990
49. Alcohol dependence: Women, biology, and pharmacotherapy
50. Psychopathology as a predictor of treatment outcome in alcoholics
51. Placebo-controlled study of sertraline in depressed recently abstinent alcoholics
52. Naltrexone utility in depressed alcoholics
53. How much is too much? Estimates of hazardous drinking based on clients' self-reports
54. Treating problem drinkers who are not severely dependent on alcohol
55. 5-HT and alcohol abuse
56. 3 antagonist ondansetron in alcohol abuse and dependence
57. Conceptual issues regarding goals in the treatment of alcohol problems
58. Reliability of a timeline method: Assessing normal drinkers' reports of recent drinking and a comparative evaluation across several populations
59. Structured Clinical Interview for DSM-III-R
60. Assessment of alcohol withdrawal: The revised Clinical Institute Withdrawal Assessment for Alcohol Scale (CIWA-Ar)
61. Effects of long-term administration of Hypericum extracts on the affinity and density of the central serotonergic 5-HT(1A) and 5-HT(2A) receptors
62. Treatment of comorbid generalized anxiety in a recently detoxified alcoholic population with a selective serotonergic drug (buspirone)
63. Impact of depressive symptomatology on alcohol problems in women
64. The structure of depression in alcoholic women
65. Dexfenfluramine: Its place in weight control
66. Randomized controlled trial of general practitioner intervention in patients with excessive alcohol consumption
67. Ritanserin in relapse prevention in abstinent alcoholics: Results from a placebo-controlled double-blind international multi-center trial
68. Combination pharmacotherapy in nalmefene non-responders
69. Amphetamine and fenfluramine suppress ethanol intake in ethanol-dependent rats