Aberrant pH of melanosomes in pink-eyed dilution (p) mutant melanocytes

Journal of Investigative Dermatology

Volumn 115, Issue 4, 2000, Pages 607-613

  Puri, Neelu ^a,b   Gardner, John M ^a   Brilliant, Murray H ^a  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Oculocutaneous albinism; P protein; Pigmentation; Tyrosinase

Indexed keywords

MELANIN; MONOPHENOL MONOOXYGENASE; TYROSINE;

ALBINISM; ANIMAL CELL; ARTICLE; CONFOCAL LASER MICROSCOPY; ENZYME ACTIVITY; GENE MUTATION; HYPOPIGMENTATION; IMMUNOHISTOCHEMISTRY; MELANOCYTE; MELANOSOME; MOUSE; NONHUMAN; OCULOCUTANEOUS ALBINISM; PH; PRIORITY JOURNAL;

EID: 0033778117     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.2000.00108.x     Document Type: Article

References (38)

1. Chloride channels of intracellular organelles
2. Vesicles and cisternae in the trans Golgi apparatus of human fibroblasts are acidic compartments
3. Visualization of acidic organelles in intact cells by electron microscopy
4. pH of melanosomes of B16 murine melanoma is acidic: Its physiological importance in the regulation of melanin biosynthesis
5. The mouse pink-eyed dilution locus: A model for aspects of Prader-Willi syndrome, Angelman syndrome, and a form of hypomelanosis of Ito
6. Two new genes PHO86 and PHO87, involved in inorganic phosphate uptake in Saccharomyces cerevisiae
7. Nucleotide sequence of the structural genes for an anion pump
8. pH-dependent interconvertible allosteric forms of murine melanoma tyrosinase. Physiological implications
9. African origin of an intragenic deletion of the human P gene in tyrosinase positive oculocutaneous albinism (OCA2)
10. Melanosomal tyrosine transport in normal and pink-eyed dilution murine melanocytes
11. The mouse pink-eyed dilution gene: Association with human Prader-Willi and Angelman syndromes
12. Tyrosinase from two different loci are expanded by normal and by transformed melanocytes
13. Tyrosinase isozyme heterogeneity in differentiating B16/C3 melanoma
14. Mutations of the p gene in oculocutaneous albinism, and Prader-Willi syndrome plus albinism
15. Organization and sequence of the human P gene and identification of a new family of transport proteins
16. A very large protein with diverse functional motifs is deficient in rjs (runty, jerky, sterile) mice
17. Genetic and molecular analysis of recessive alleles at the pink-eyed dilution locus
18. Effects of genotype and cellular environment on melanoblast differentiation in the house mouse
19. Regulation of melanogenesis in melanocytes
20. A cluster of three GABA(A) receptor subunit genes is deleted in a neurological mutant of the mouse p locus
21. Molecular analysis of the cDNAs encoded by the p(J) and p(un) alleles of the pink-eyed dilution locus
22. The clinical spectrum of albinism in humans
23. Melanosomes are specialized members of the lysosomal lineage of organelles
24. The pink-eyed dilution locus controls the biogenesis of melanosomes and levels of melanosomal proteins in the eye
25. Chemical characterization of hair melanins in various coat color mutants of mice
26. The enzymology of melanogenesis
27. Normal tyrosine transport and abnormal tyrosinase routing in pink-eyed dilution melanocytes
28. Biological applications of ionophores
29. Comparative analysis of melanins and melanosomes produced by various coat color mutants
30. Lag kinetics of tyrosinase: Its physiological implications
31. A gene for the mouse pink-eyed dilution locus and for human type II oculocutaneous albinism
32. Identification of a melanosomal membrane protein encoded by the pink-eyed dilution (type II oculocutaneous albinism) gene
33. Melanosomal defects in melanocytes from mice lacking expression of the pink-eyed dilution (p) gene: Correction by culture in the presence of excess tyrosine
34. A quantitative histological study of the pigment found in coat colour mutants of the house-mouse. The nature of genetic effects of five major allelic series
35. Pink-eyed dilution (p) gene in rodents: Increased pigmentadon in tissue culture
36. Acidification of lysosomes and endosomes
37. Biosynthesis and intracellular movement of the melanosomal membrane glycoproteni gp75, the human b (brown) locus product
38. Intracellular sorting and targeting of melanosomal membrane proteins: Identification of signals for sorting of the human brown locus protein, Gp75