Addition of sodium bicarbonate to lidocaine decreases the duration of peripheral nerve block in the rat

Anesthesiology

Volumn 93, Issue 4, 2000, Pages 1045-1052

  Sinnott, Catherine J ^a   Garfield, Joseph M ^a   Thalhammer, Johannes G ^b   Strichartz, Gary R ^a,c  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b Medizinische Klinik

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Adjuvant; Epinephrine; Local anesthesia

Indexed keywords

ADRENALIN; BICARBONATE; LIDOCAINE; SODIUM HYDROXIDE;

ALKALINIZATION; ANALGESIA; ANIMAL EXPERIMENT; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; DRUG FORMULATION; MALE; NERVE BLOCK; NONHUMAN; PERIPHERAL NERVE; PH; PRIORITY JOURNAL; RAT;

EID: 0033775501     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-200010000-00028     Document Type: Article

References (15)

1. The effect of pH adjustment of 1% lidocaine on the onset of sensory and motor blockade of epidural anesthesia in nonpregnant gynecological patients
2. Adding sodium bicarbonate to lidocaine enhances the depth of epidural blockade
3. Effects of pH adjustment and carbonation of lidocaine during epidural anesthesia for foot and ankle surgery
4. Alkalization of lidocaine does not hasten the onset of axillary brachial plexus block
5. The effect of bicarbonate on mixtures of lidocaine, bupivacaine and hyaluranidase with or without epinephrine
6. Neurologic evaluation of the rat during sciatic nerve block with lidocaine
7. Relation between functional deficit and intraneural local anesthetic during peripheral nerve block
8. Alkalinization of lidocaine 2% does not influence the quality of epidural anesthesia for elective Caesarean section
9. Effect of pH modification by bicarbonate on pain after subcutaneous lidocaine injection
10. pH adjustment of local anesthetic solutions with sodium bicarbonate: Laboratory evaluation of alkalinization and precipitation
11. Potentiation of two different local anesthetics by carbon dioxide
12. On the mode of action of local anesthetics
13. On the mechanisms of potentiation of local anesthetics by bicarbonate buffer: Drug structure-activity studies on isolated peripheral nerve
14. 2 and pH on local anesthetic action
15. 2