Adaptation to alkylation damage in DNA measured by the comet assay

Environmental and Molecular Mutagenesis

Volumn 36, Issue 2, 2000, Pages 146-150

  Hyland, P L ^a   Keegan, A L ^a   Curran, M D ^a,b   Middleton, D ^a,b,c   McKenna, P G ^c   Barnett, Y A ^c  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b BELFAST CITY HOSPITAL   (United Kingdom)

^c UNIVERSITY OF ULSTER   (United Kingdom)

Author keywords

Abasic (AP) sites; AP endanuclease; Cell cycle; Cyclaheximide; Single strand breaks; Vicia faba

Indexed keywords

CYCLOHEXIMIDE; DNA; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE; EXODEOXYRIBONUCLEASE III; MESYLIC ACID METHYL ESTER; METHYLNITROSOUREA;

APURINIC SITE; ARTICLE; CELL CYCLE; CELL NUCLEUS; COMET ASSAY; CONTROLLED STUDY; DNA ALKYLATION; DNA DAMAGE; DNA STRAND BREAKAGE; NONHUMAN; PLANT GROWTH; PLANT ROOT; PROTEIN SYNTHESIS INHIBITION; VICIA FABA;

EID: 0033775047     PISSN: 08936692     EISSN: None     Source Type: Journal    
DOI: 10.1002/1098-2280(2000)36:2<146::AID-EM9>3.0.CO;2-5     Document Type: Article

References (23)

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3. 6-methylguanine from plant DNA in vivo is accelerated under conditions of clastogenic adaptation
4. Distribution of methyl and ethyl adducts following alkylation with monofunctional alkylating agents
5. UV-B-induced PR-1 accumulation is mediated by active oxygen species
6. Transcriptional activation of apurinic/apyrimidinic endonuclease (Ape, Ref-1) by oxidative stress requires CREB
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8. Critical steps in alkylation-induced aberration formation
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14. Mutagenesis by apurinic/apyrimidinic sites
15. Issues related to the experimental design and subsequent statistical analysis of in vivo and in vitro comet studies
16. Activation of apurinic/ apyrimidinic endonuclease in human cells by reactive oxygen species and its correlation with their adaptive response to genotoxicity of free radicals
17. Specific checkpoints regulate plant cell cycle progression in response to oxidative stress
18. Inducible repair processes in plant meristems? 'Below-additivity effects' of unequally fractionated clastogen concentrations
19. On adaptive responses of plant meristem cells in vivo: Protection against induction of chromatid aberration
20. Cloning of a 3-methyladenine-DNA glycosylase from Arabidopsis thaliana
21. Are SCE frequencies indicative of adaptive response of plant cells?
22. Intrachromosomal distribution patterns of mutagen-induced SCEs and chromatid aberrations in reconstructed karyotypes of Vicia faba
23. Control points within the cell cycle