Thienocoumarin derivatives: Interaction with nucleic acids and synthetic polydeoxyribonucleotides

Journal of Photochemistry and Photobiology B: Biology

Volumn 56, Issue 2-3, 2000, Pages 132-138

  Gia, Ornella ^a   Dalla Via, Lisa ^a   Marciani Magno, Sebastiano ^a   Angelini, Giancarlo ^b   Margonelli, Andrea ^b   Rodighiero, Paolo ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b Area della Ricerca di Roma   (Italy)

Author keywords

Antiproliferative activity; Photobiological properties; Skin phototoxicity; Thienocoumarins

Indexed keywords

4,6,9 TRIMETHYL 2H THIENOL(3,2 G) 1 BENZOPYRAN 2 ONE; 6,9 DIMETHYL 4 METHOXYMETHYL 2H THIENOL(3,2 G) 1 BENZOPYRAN 2 ONE; BACTERIAL DNA; COUMARIN DERIVATIVE; DNA; EDETIC ACID; FUROCOUMARIN; METHOXSALEN; NUCLEIC ACID; POLYDEOXYRIBONUCLEOTIDE; SODIUM CHLORIDE; THIENOCOUMARIN DERIVATIVE; TRIOXYSALEN; TRITIUM; TRYPAN BLUE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; DNA BINDING; DNA CROSS LINKING; DNA HELIX; DNA STRAND; DRUG ACTIVITY; DRUG BINDING; DRUG POTENCY; DRUG STRUCTURE; GROWTH INHIBITION; HUMAN; HUMAN CELL; ISOTOPE LABELING; NONHUMAN; PHOTOREACTIVITY; PHOTOTOXICITY; PRIORITY JOURNAL; TUMOR CELL LINE;

ANIMAL; CATTLE; CELL DIVISION; COUMARINS; DNA; DNA, BACTERIAL; HL-60 CELLS; HUMAN; KINETICS; METHOXSALEN; PHOTOSENSITIZING AGENTS; POLYDEOXYRIBONUCLEOTIDES; SKIN; SUPPORT, NON-U.S. GOV'T; THIOPHENES; TUMOR CELLS, CULTURED; ULTRAVIOLET RAYS;

EID: 0033774762     PISSN: 10111344     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1011-1344(00)00064-6     Document Type: Article

References (23)

1. The evolution of photochemotherapy with psoralens and UVA (PUVA): 2000 BC to 1992 AD
2. Psoralen photobiology and photochemotherapy: 50 years of science and medicine
3. Recent advances in psoralen phototoxicity mechanism
4. Clinical and mechanistic aspects of photopheresis
5. Photophysical behaviour of new pyrrolocoumarin derivatives
6. Pyrrolocoumarin derivatives as potential photoreagents toward DNA
7. Angular furoquinolinones, psoralen analogs: Novel antiproliferative agents for skin diseases. Synthesis, biological activity, mechanism of action, and computer-aided studies
8. 1-Thiomethoxalen and 1-thiopsoralen: Synthesis, photobiological properties, and site specific reaction of thiopsoralens with DNA
9. Photobiological activity of sulphur and selenium analogues of psoralen
10. Synthesis and biological activity of linear and angular 4-methoxymethylthienocoumarins and 4-acetoxymethyl-thienocoumarins
11. Recent and selected aspects of furocoumarin photochemistry and photobiology
12. Psoralens as photoactive probes of nucleic acid structure and function: Organic chemistry, photochemistry and biochemistry
13. Tritium labelling of some new psoralen derivatives. The thienocoumarin framework
14. Determination of the base composition of the deoxyribonucleic acid from its thermal denaturation temperature
15. Instrument for the studies of differential flow dichroism of polymer solutions
16. Spectroscopic properties and photoreactivity with DNA of new monofunctional pyridopsoralen
17. Photoreactions between skin-photosensitizing furocoumarins and nucleic acids
18. Angelicins, angular analogs of psoralens: Chemistry, photochemical, photobiological and phototherapeutic properties
19. Interaction between DNA and 8-methoxypsoralen studied by linear dichroism
20. New tetracyclic analogues of photochemotherapeutic drugs 5-MOP and 8-MOP: Synthesis, DNA interaction and antiproliferative activity
21. Photobiological activity of 3,4'-dimethyl-8-methoxypsoralen, a linear furocoumarin with unusual DNA-binding properties
22. 4'-Methyl derivatives of 5-MOP and 5-MOA: Synthesis, photoreactivity, and photobiological activity