Inhibition of the cyclooxygenase/lipoxygenase pathways to improve interferon alpha efficacy in chronic hepatitis C: Don't lose the tract! [1]

Digestive and Liver Disease

Volumn 32, Issue 6, 2000, Pages 542-543

  Andreone, P ^a   Gramenzi, A ^a   Cursaro, C ^a   Bernardi, M ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; ARACHIDONIC ACID; INDOMETACIN; KETOPROFEN; LIPOXYGENASE; LIPOXYGENASE INHIBITOR; MESALAZINE; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR; TENOXICAM;

ANTIVIRAL ACTIVITY; CHRONIC HEPATITIS; CLINICAL PRACTICE; CLINICAL PROTOCOL; CLINICAL TRIAL; COMBINATION CHEMOTHERAPY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG ABSORPTION; DRUG ACTIVITY; DRUG EFFICACY; DRUG MECHANISM; ENZYME INHIBITION; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; IMMUNE RESPONSE; IMMUNOREACTIVITY; LETTER; RANDOMIZED CONTROLLED TRIAL;

ANTIVIRAL AGENTS; CLINICAL TRIALS; CYCLOOXYGENASE INHIBITORS; DRUG INTERACTIONS; DRUG THERAPY, COMBINATION; HEPATITIS C; HUMANS; INTERFERON-ALPHA; LIPOXYGENASE INHIBITORS; REPRODUCIBILITY OF RESULTS; SAMPLE SIZE; VIRAL LOAD;

EID: 0033774685     PISSN: 11258055     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Letter

References (12)

1. Interferon alpha plus ketoprofen or interferon alpha plus ribavirin in chronic hepatitis C non-responder to interferon alpha alone: Results of a pilot study
2. Inhibition of the cyclooxygenase/lipoxygenase pathways to improve interferon alfa efficacy in chronic hepatitis C: A wrong track
3. Signal transduction by interferon alpha through arachidonic acid metabolism
4. Tenoxicam, a non-steroidal anti-inflammatory drug, is unable to increase the response rate in patients with chronic hepatitis C treated by alpha interferon
5. Tenoxicam. An update of its pharmacology and therapeutic efficacy in rheumatic diseases
6. Indomethacin enhances serum 2'5'-oligoadenylate synthetase in patients with hepatitis B and C virus chronic active hepatitis
7. Non-steroidal anti-inflammatory drug metabolism potentiates interferon alfa signaling by increasing STAT1 phosphorylation
8. Modulation of Th1/Th2 cytokine profile and antiviral response by interferon α (IFNα) and non steroidal anti-inflammatory drugs (NSAIDs) in hepatitis C virus (HCV)
9. Interferon alfa-2b alone or in combination with ketoprofen as treatment for interferon-naive chronic hepatitis C patients
10. Interferon-α 2b combined with daily ketoprofen administration improves virological response in chronic hepatitis C: A prospective and randomized trial
11. Interferon signalling through arachidonic acid-dependent pathways: A clue to adjuvant therapy for chronic viral hepatitis?
12. Interferon-α plus indomethacin combined therapy in HBeAg positive chronic hepatitis B non-responder to a previous IFN-α course: Results of a pilot study