Physiologically-based pharmacokinetic analysis of grepafloxacin

Biological and Pharmaceutical Bulletin

Volumn 23, Issue 9, 2000, Pages 1077-1083

  Nakajima, Yukiko ^a   Hattori, Kenji ^a   Shinsei, Machiko ^a   Matsunaga, Noriko ^a   Iizasa, Hisashi ^a   Sasabe, Hiroyuki ^b   Akiyama, Hitoshi ^b   Miyamoto, Gohachiro ^b   Nakashima, Emi ^a  

^a KEIO UNIVERSITY   (Japan)

^b OTSUKA PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Animal scale up; Grepafloxacin; Physiological pharmacokinetic model; Tissue distribution

Indexed keywords

1 CYCLOPROPYL 5 ETHYL 6,8 FLUORO 7 (4 METHYL 1 PIPERAZINYL) 4 OXOQUINOLINE CARBOXYLIC ACID; GREPAFLOXACIN; OPC 17203; QUINOLINE DERIVED ANTIINFECTIVE AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOG; DOSE TIME EFFECT RELATION; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG STRUCTURE; DRUG TISSUE LEVEL; MALE; MONKEY; NONHUMAN; PARTITION COEFFICIENT; PREDICTION; RABBIT; RAT; SIMULATION; SPECIES DIFFERENCE;

EID: 0033774028     PISSN: 09186158     EISSN: None     Source Type: Journal    
DOI: 10.1248/bpb.23.1077     Document Type: Article

References (24)