Conformations of the regulatory domain of cardiac troponin C examined by residual dipolar couplings

European Journal of Biochemistry

Volumn 267, Issue 22, 2000, Pages 6665-6672

  Pääkkönen, Kimmo ^a   Sorsa, Tia ^b   Drakenberg, Torbjörn ^c   Pollesello, Piero ^d   Tilgmann, Carola ^a   Permi, Perttu ^b   Heikkinen, Sami ^c   Kilpeläinen, Ilkka ^a   Annila, Arto ^a,d  

^a VTT TECHNICAL RESEARCH CENTRE OF FINLAND   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

^c ORION CORPORATION   (Finland)

^d UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Calcium dependent binding; Cardiac troponin; Conformational exchange; NMR; Residual dipolar couplings

Indexed keywords

AMINO ACID; CALCIUM ION; REGULATOR PROTEIN; TROPONIN C;

ARTICLE; BINDING SITE; CALCIUM BINDING; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; EXCITATION CONTRACTION COUPLING; HEART MUSCLE; LIQUID CRYSTAL; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; SKELETAL MUSCLE;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; MODELS, MOLECULAR; MUSCLE, SKELETAL; MYOCARDIUM; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TROPONIN C; TROPONIN I;

EID: 0033773598     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.2000.01763.x     Document Type: Article

References (50)

1. Structural aspects of troponintropomyosin regulation of skeletal muscle contraction
2. 2+ regulation of muscle contraction
3. Control of muscle contraction
4. 2+-switch in the calmodulin superfamily
5. Structural details of a calcium-induced molecular switch: X-ray crystallographic analysis of the calcium-saturated N-terminal domain of troponin C at 1.75 A resolution
6. Quantification of the calcium-induced secondary structural changes in the regulatory domain of troponin-C
7. Structures of the troponin C regulatory domains in the apo and calcium-saturated states
8. Backbone and methyl dynamics of the regulatory domain of troponin C: Anisotropic rotational diffusion and contribution of conformational entropy to calcium affinity
9. Molecular mechanism of troponin-C function
10. NMR solution structure of calcium-saturated skeletal muscle troponin C
11. 2- and COOH-terminal regions of skeletal muscle troponin I
12. 2 terminus of fast skeletal muscle roponin I in its biological activity
13. Reconstitution of skinned cardiac fibres with human recombinant cardiac troponin-I mutants and troponin-C
14. Photo-cross-linking of rabbit skeletal troponin I deletion mutants with troponin C and its thiol mutants: The inhibitory region enhances binding of troponin I fragments to troponin C
15. Structure of the troponin complex. Implications of photocross-linking of troponin I to troponin C thiol mutants
16. Interaction of the second binding region of troponin I with the regulatory domain of skeletal muscle troponin C as determined by NMR spectroscopy
17. NMR studies delineating spatial relationships within the cardiac troponin I-troponin C complex
18. Cardiac troponin I induced conformational changes in cardiac troponin C as monitored by NMR using site-directed spin and isotope labeling
19. An NMR and spin label study of the effects of binding calcium and troponin I inhibitory peptide to cardiac troponin C
20. The amino acid sequence of bovine cardiac tamponin-C. Comparison with rabbit skeletal troponin-C
21. Structure of cardiac muscle troponin C unexpectedly reveals a closed regulatory domain
22. Calcium-induced structural transition in the regulatory domain of human cardiac troponin C
23. Solution structure and main chain dynamics of the regulatory domain (residues 1-91) of human cardiac troponin C
24. 2+-saturated state
25. 2+ binding and conformational changes in a calmodulin domain
26. Effects of troponin I phosphorylation on conformational exchange in the regulatory domain of cardiac troponin C
27. Binding of cardiac troponin-I147-163 induces a structural opening in human cardiac troponin-C
28. Direct measurement of distances and angles in biomolecules by NMR in a dilute liquid crystalline medium
29. High-resolution heteronuclear NMR of human ubiquitin in an aqueous liquid crystalline medium
30. Tunable alignment of macromolecules by filamentous phage yields dipolar coupling interactions
31. Solution structure of the 40,000 Mr phosphoryl transfer complex between the N-terminal domain of enzyme I and HPr
32. Recognition of protein folds via residual dipolar couplings
33. Order matrix analysis of residual dipolar couplings using singular value decomposition
34. Variation of molecular alignment as a means of resolving orientational ambiguities in protein structures from dipolar couplings
35. Orienting domains in proteins using dipolar couplings measured by liquid-state NMR: Differences in solution and crystal forms of maltodextrin binding protein loaded with beta-cyclodextrin
36. Solid phase peptide synthesis utilizing 9-fluorenylmethoxycarbonyl amino acids
37. Ultraviolet absorbance and circular dichroism of Pf1 virus: Nucleotide/subunit ratio of unity, hyperchromic tyrosines and DNA bases, and high helicity in the subunits
38. Doublet-separated sensitivity-enhanced HSQC for the determination of scalar and dipolar one-bond J-couplings
39. Torsion angle dynamics for NMR structure calculation with the new program DYANA
40. Direct structure refinement against residual dipolar couplings in the presence of rhombicity of unknown magnitude
41. Bicelle-based liquid crystals for NMR-measurement of dipolar couplings at acidic and basic pH values
42. Refined structure of chicken skeletal muscle troponin C in the two-calcium state at 2-A resolution
43. Low-temperature-induced structural changes in the Apo regulatory domain of skeletal muscle troponin C
44. Structures of the troponin C regulatory domains in the apo and calcium-saturated states
45. Pervasive conformational fluctuations on microsecond time scales in a fibronectin type III domain
46. Transverse relaxation optimised spin-state selective NMR experiments for measurement of residual dipolar couplings
47. 2H) labeled proteins
48. 2+ affinity by drugs
49. 2+ sensitizer, levosimendan, to recombinant human cardiac troponin C. A molecular modelling, fluorescence probe, and proton nuclear magnetic resonance study