Characterization of oleic acid and propranolol oleate mesomorphism using 13C solid-state nuclear magnetic resonance spectroscopy (SSNMR)

Journal of Pharmaceutical Sciences

Volumn 89, Issue 10, 2000, Pages 1286-1295

  Crowley, Kieran J ^a   Forbes, Robert T ^a   York, Peter ^a   Apperley, David C ^b   Nyqvist, Håkan ^c   Camber, Ola ^c  

^a UNIVERSITY OF BRADFORD   (United Kingdom)

^b DURHAM UNIVERSITY   (United Kingdom)

^c ASTRAZENECA R AND D   (Sweden)

Author keywords

13C Solid state nuclear magnetic resonance spectroscopy; Conformational disorder; Mesophase; Oleic acid; Propranolol oleate

Indexed keywords

LIPID; OLEIC ACID; PROPRANOLOL; PROPRANOLOL DERIVATIVE; PROPRANOLOL OLEATE; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG CONFORMATION; DRUG FORMULATION; DRUG PURITY; DRUG STABILITY;

EID: 0033771769     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/1520-6017(200010)89:10<1286::AID-JPS6>3.0.CO;2-O     Document Type: Article

References (25)

1. Characteristics of lipid substances activating the ileal brake in the rat
2. Modification of intestinal absorption of drugs by lipoidal adjuvants
3. Transport of lipophilic molecules by the intestinal lymphatic system
4. Structural classification of liquid crystals
5. Electron and light microscopical investigation of defect structures in mesophases of pharmaceutical substances
6. Temperature dependence of molecular conformation and liquid structure of cis-9-octadecenoic acid
7. 1H magic angle spinning NMR study
8. Solid state nuclear magnetic resonance spectroscopy - Theory and pharmaceutical applications
9. Solid-state analysis of polymorphic, isomorphic, and solvated forms of dirithromycin
10. Quantitation of the relative amounts of anhydrous carbamazepine and carbamazepine dihydrate in a mixture by solid-state nuclear magnetic resonance (NMR)
11. Molecular mobility in mixtures of absorbed water and solid poly(vinylpyrrolidone)
12. 4 receptor antagonist
13. Crystallization and transformation mechanisms of α-, β-, and γ-polymorphs of ultra pure oleic acid
14. Vibrational spectroscopic study on polymorphism and order-disorder phase transition in oleic acid
15. Oleate salt formation and mesomorphic behavior in the propranolol/oleic acid binary system
16. 1 values by a method which suppresses artifacts
17. Carbon-13 Fourier transform nuclear magnetic resonance. VIII. Role of steric and electric field effects in fatty acid specta
18. Selection of nonprotonated carbon resonances in solid-state nuclear magnetic resonance
19. Mechanism for the enhancement effect of fatty acids on the percutaneous absorption of propranolol
20. An investigation into the effect of preparation conditions on the structure and mechanical properties of pharmaceutical glyceride bases