Inhibition of NO production in macrophages by IL-13 is counteracted by Herpes simplex virus infection through TNF-α-induced activation of NF-κB

European Cytokine Network

Volumn 11, Issue 2, 2000, Pages 275-282

  Paludan, S R ^a   Ellermann Eriksen, S ^a   Malmgaard, L ^a   Mogensen, S C ^a  

^a AARHUS UNIVERSITY   (Denmark)

Author keywords

Herpes simplex virus; IFN ; IL 13; Macrophages; NF B; TNF

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 13; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; STAT6 PROTEIN; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA ANTIBODY;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; HERPES SIMPLEX; HERPES SIMPLEX VIRUS 2; IMMUNOSTIMULATION; MACROPHAGE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; VIRUS REPLICATION;

ANIMAL; BASE SEQUENCE; CELLS, CULTURED; DNA PRIMERS; FEMALE; HERPES GENITALIS; HERPESVIRUS 2, HUMAN; INTERFERON TYPE II; INTERLEUKIN-13; MACROPHAGES; MICE; MICE, INBRED BALB C; NF-KAPPA B; NITRIC OXIDE; SIGNAL TRANSDUCTION; SUPPORT, NON-U.S. GOV'T; TUMOR NECROSIS FACTOR; VIRUS REPLICATION;

EID: 0033769763     PISSN: 11485493     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. Activated macrophages destroy intracellular Leishmania major amastigotes by an L-arginine-dependent killing mechanism
2. L-arginine-dependent macrophage effector functions inhibit metabolic activity of Mycobacterium leprae
3. Evidence for an antiviral effect of nitric oxide. Inhibition of herpes simplex virus type 1 replication
4. Inhibition of viral replication by interferon-γ-induced nitric oxide synthase
5. Mice lacking inducible nitric-oxide synthase are more susceptible to herpes simplex virus infection despite enhanced Th1 cell responses
6. Differential inhibitory action of nitric oxide and peroxynitrite on mitochondrial electron transport
7. Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation. Formation of novel nitrogen-containing oxidized lipid derivatives
8. DNA damage induced by peroxynitrite: Subsequent biological effects
9. Induction of macrophage nitric oxide production by interferon-γ and tumor necrosis factor-α is enhanced by IL-10
10. Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon and bacterial lipopolysaccharide
11. Herpes simplex virus type 2 synergizes with interferon-γ in the induction of nitric oxide production in mouse macrophages through autocrine secretion of tumour necrosis factor-α
12. Mechanism of suppression of nitric oxide synthase expression by IL-4 in primary mouse macrophages
13. IL-10 inhibits parasite killing and nitrogen oxide production by IFN-γ-activated macrophages
14. Modulation of murine macrophage function by IL-13
15. Mechanisms of suppression of macrophage nitric oxide release by transforming growth factor-β
16. Macrophage nitric oxide synthase gene: Two upstream regions mediate induction by interferon-γ and lipopolysaccharide
17. Requirement for transcription factor IRF-1 in NO synthase induction in macrophages
18. Role of transcription factor NF-κB/Rel in induction of nitric oxide synthase
19. NF-κB/Rel activation is responsible for the synergistic effect of herpes simplex virus type 2 infection on interferon-γ-induced nitric oxide production in macrophages
20. Interleukin-4 and interleukin-13: Their similarities and discrepancies
21. Interleukin-4 and interleukin-13: Same response, different receptors
22. Impaired IL-13 mediated function of macrophages in STAT-6 deficient mice
23. Interleukin-4 and interleukin-13 differentially regulate epithelial chloride secretion
24. Comparison of the regulations by Th2-type cytokines of the arachidonic-acid metabolic pathway in human alveolar macrophages and monocytes
25. Interleukin-13 but not interleukin-4 prolongs eosinophil survival and induces eosinophil chemotaxis
26. Interleukin-4 down-regulates both forms of tumor necrosis factor receptor and receptor-mediated apoptosis, NF-kappaB, AP-1, and c-Jun N-terminal kinase. Comparison with interleukin-13
27. The related cytokines interleukin-13 and interleukin-4 are distinguished by differential production and differential effects on T lymphocytes
28. Effect of IL-4 and IL-13 on IFN-γ-induced production of nitric oxide in mouse macrophages infected with herpes simplex virus type 2
29. Herpes simplex virus infection of macrophages impairs IL-4-mediated inhibition of NO production through TNF-α-induced activation of NF-κB
30. Autocrine secretion of interferon-α/β and tumour necrosis factor-α synergistically activates mouse macrophages after infection with herpes simplex virus type 2
31. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
32. IL-4-induced expression of the IL-1 receptor antagonist gene is mediated by STAT6
33. Effects of IL-13 on phenotype, cytokine production, and cytotoxic function of human monocytes. Comparison with IL-4 and modulation by IFN-γ or IL-10
34. In vivo suppression of NF-κB and preservation of IκBα by interleukin-10 and interleukin-13
35. Suppression of herpes simplex virus type 1 (HSV-1)-induced pneumonia in mice by inhibition of inducible nitric oxide synthase (iNOS, NOS2)
36. Nitric oxide accelerates the onset and increases the severity of experimental autoimmune uveoretinitis through an IFN-γ-dependent mechanism
37. Chloromethyl ketones block induction of nitric oxide synthase in murine macrophages by preventing activation of nuclear factor κB
38. PPAR-γ agonists inhibit production of monocyte inflammatory cytokines
39. The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation
40. Interleukin-4-dependent production of PPAR-γ ligands in macrophages by 12/15-lipoxygenase
41. Induction of NO synthesis in macrophages by Newcastle disease virus is associated with activation of nuclear factor-κB
42. Viral induction of the human b interferon promoter: Modulation of transcription by NF-κB/rel proteins and interferon regulatory factors
43. High adenovirus loads stimulate NF-κB-dependent gene expression in human vascular smooth muscle cells
44. The Epstein-Barr virus oncogene product latent membrane protein 1 engages the tumor necrosis factor receptor-associated death domain protein to mediate B lymphocyte growth transformation and activate NF-κB