Micronucleus test with a metabolic activation system and cultured rat astrcytes

Jikeikai Medical Journal

Volumn 47, Issue 3, 2000, Pages 131-138

  Sakaba, H ^a   Liu, D ^a   Tsukui, M ^a   Asanuma, K ^a   Takahashi, A ^a   Suzuki, Y ^a  

^a JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

5 Fluorouracil; Cyclophosphamide; Metabolic activation; Micronuclei; Rat astrocyte

Indexed keywords

CYCLOPHOSPHAMIDE; FLUOROURACIL;

ANIMAL CELL; ARTICLE; ASTROCYTE; BRAIN CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; GENOTOXICITY; IN VITRO STUDY; INCUBATION TIME; MALE; METABOLIC ACTIVATION; MICRONUCLEUS TEST; NEUROTOXICITY; NEWBORN; NONHUMAN; RAT; SCREENING TEST; SUPERNATANT;

EID: 0033767923     PISSN: 00216968     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Guideline for testing of chemicals
2. The induction of micronuclei as a measure of genotoxicity, A report of the US Environmental Protection Agency Gene-Tox Program
3. Primary brain tumors associated with chemical exposure
4. In vitro micronucleus assay of 30 chemicals in CHL cells
5. Induction of micronucleus in NSC19 motoneuron cell line by genotoxic chemicals
6. Micronucleus test using cultured new born rat astrocytes
7. In vitro micronucleus test for six chemicals using cultured rat astrocytes
8. Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue
9. A safe substitute for polychlorinated biphenyls as an inducer of metabolic activation system
10. Tables for determining the statistical significance of mutation frequencies
11. Cyclophosphamide: Review of its mutagenicity for an assessment of potential germ cell risks
12. Studies on fluorinated pyrimidines. VII. The degradative pathway
13. Metabolism and mechanism of action of 5-fluorouracil
14. Kinetics of micronucleus formation in relation to chromosomal aberrations in mouse bone marrow
15. The production of micronuclei from chromosome aberrations irradiated cultures of human lymphocytes
16. Immunohistochemical characterization of rat central and peripheral nerve tumors induced by ethylnitrosourea
17. Histopathological studies of the nervous system tumors in rats induced by N-nitrosomethylurea
18. Studies of N, N'-dimethylnitrosourea-induced brain tumors in rats-especially, on microtumors
19. Carcinogenecity of nitrosotrialkylurea in Fisher 344 rats
20. Induction of tumors of the nervous system in the ACI/N rat with 1-butyl-1-nitorourea administered transplacentally, neonatally, or via material milk
21. Comparative tumorigenicity of N-nitroso-2-hydroxymorpholine, N-nitrosodiethanolamine and N-nitrosomorpholine in A/J mice and F344 rats
22. Transplacental induction of tumors in Sprague-Dawley rats with crude cycad material
23. Carcinogenic activity of 1-Phenyl- and 1(Pyridyl-3)-3, 3-dimethyl-triazene and of 1-Phenyl- and 1- (Pridyl-3)-3, 3-diethyl-triazene by single pre- and postnatal application to BD IX rats
24. Age dependence of susceptibility to carcinogenesis in the nervous system
25. Induction of rat kidney tumors by ethyl methanesulphonate and nervous tissue tumours by methyl methanesulphonate and ethyl methanesulphonate
26. Carcinogenecity tests of certain environmental and industrial chemicals