Synthesis and biological activity of the penem antibiotic MEN 10700 and its orally absorbed ester MEN 11505

Journal of Antibiotics

Volumn 53, Issue 10, 2000, Pages 1086-1095

  Arcamone, F M ^a   Altamura, M ^a   Perrotta, E ^a   Crea, A ^a   Manzini, S ^a   Poma, D ^a   Salimbeni, A ^a   Triolo, A ^a   Maggi, C A ^a  

^a CNR   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2 [N (2 ACETAMIDO) N METHYL]AMINOMETHYL 6 (1 HYDROXYETHYL) PENEM 3 CARBOXYLIC ACID; 2 [N (2 ACETAMIDO) N METHYL]AMINOMETHYL 6 (1 HYDROXYETHYL)PENEM 3 CARBOXYLIC ACID PIVALOYLOXYMETHYL ESTER; 2 [[[6 (1 HYDROXYETHYL) 2 METHYL 7 OXO 4 THIA 1 AZABICYCLO[3.2.0]HEPT 2 EN 3 YL]METHYL]METHYLAMINO]ACETAMIDE; 6 (1 HYDROXYETHYL) 4 METHYL 7 OXO 3 (5 OXO 3 PYRROLIDINYLTHIO) 1 AZABICYCLO[3.2.0]HEPT 2 ENE 2 CARBOXYLIC ACID PIVALOYLOXYMETHYL ESTER; ANTIBIOTIC AGENT; AZETIDINONE DERIVATIVE; BETA LACTAMASE; CARBAPENEM; CEFOTAXIME; CEFTAZIDIME; CEPHALOSPORINASE; CIPROFLOXACIN; FROPENEM; IMIPENEM; KIDNEY ENZYME; MEN 11505; METRONIDAZOLE; PENEM DERIVATIVE; PRODRUG; RITIPENEM; RITIPENEM ACOXIL; SANFETRINEM; UNCLASSIFIED DRUG;

ANAEROBIC BACTERIUM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DEGRADATION; DRUG POTENCY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENTEROBACTERIACEAE; ENZYME ACTIVITY; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0033767015     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.53.1086     Document Type: Article

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