The use of Fluorescence Resonance Energy Transfer to study the disintegration kinetics of liposomes containing lysolecithin and oleic acid in rat plasma

Pharmaceutical Research

Volumn 17, Issue 9, 2000, Pages 1118-1123

  Madorin M ^a,b,c   Van Hoogevest, P ^d   Hilfiker, R ^e   Leuenberger, H ^b  

^a NOVARTIS PHARMA AG   (Switzerland)

^b Pharmazentrum   (Switzerland)

^c WELEDA AG   (Germany)

^d Advanced Drug Delivery ADD Technologies Ltd   (Switzerland)

^e SOLVIAS AG   (Switzerland)

Author keywords

Blood plasma; Fluorescence Resonance Energy Transfer (RET); Liposomes; Lysolecithin

Indexed keywords

LIPOSOME; LYSOPHOSPHATIDYLCHOLINE; OLEIC ACID;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING KINETICS; DRUG MONITORING; ENERGY TRANSFER; FLUORESCENCE; LIPID ABSORPTION; LIPID COMPOSITION; LIPID VESICLE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0033766789     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1026413914687     Document Type: Article

References (16)

1. Self-quenching of carboxyfluorescein fluorescence: Uses in liposomes stability and liposome-cell interactions
2. Characterization of liposomes
3. Kinetic modelling of liposome degradation in serum: Effect of size and concentration of liposomes in vitro
4. Use of resonance energy transfer to monitor membrane fusion
5. Membrane fusion in lipid vesicle systems
6. Fluorescence resonance energy transfer measurements as a tool to detect fusion and drug exchange in liposomal suspension
7. Fate of liposomes in vivo: A brief indroductory review
8. Fate of injected liposomes: Observations on entrapped solute retention, vesicle clearance and tissue distribution in vivo
9. The effect of particle size and charge on the clearance rates of liposomes and liposome encapsulated drugs
10. Properties of liposomal membranes containing lysolecithin
11. Structure of 1-acyl lysophosphatidylcholine and fatty acid complex in bilayers
12. Association of lysophosphatidylcholine with fatty acids in aqueous phase to form bilayers
13. Interactions of serum proteins with small unilamellar liposomes composed of dioleoylphosphatidylethanolamine and oleic acid: High-density lipoprotein, apolipoprotein A1, and amphipathic peptides stabilize liposomes
14. Small volume extrusion apparatus for preparation of large unilamellar vesicles
15. Preparation of liposomes encapsulating watersoluble compound using supercritical carbon dioxide
16. Tissue distribution of liposomes exhibiting long half-lives in the circulation after intravenous injection