Phenotypic expression of the systemic toxicity of cocaine in genetically epilepsy-prone rats

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 362, Issue 4-5, 2000, Pages 402-405

  Shi, Bing ^a   Heavner, James E ^a   Reigel, Charles E ^a   Kao, Y James ^a   Kaye, Alan D ^a  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER SCHOOL OF MEDICINE   (United States)

Author keywords

Arrhythmias; Cocaine induced seizures; Epilepsy; Genetically epilepsy prone rats

Indexed keywords

COCAINE; HALOTHANE; NITROUS OXIDE;

ANIMAL MODEL; ARTICLE; ASYSTOLE; CARDIOTOXICITY; CONTROLLED STUDY; DISEASE PREDISPOSITION; DISEASE SEVERITY; EPILEPSY; EPILEPTIC DISCHARGE; HEART ARRHYTHMIA; NONHUMAN; PHENOTYPE; RAT; RAT STRAIN;

ANIMALS; ARRHYTHMIA; COCAINE; ELECTROENCEPHALOGRAPHY; EPILEPSY; GAMMA-AMINOBUTYRIC ACID; GENETIC PREDISPOSITION TO DISEASE; MALE; PHENOTYPE; RATS; RATS, SPRAGUE-DAWLEY; SEIZURES;

EID: 0033766124     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002100000297     Document Type: Article

References (24)

1. Reduction of GABA and glutamate transporter messenger RNAs in the severe-seizure genetically epilepsy-prone rat
2. Regional brain abnormalities in norepinephrine uptake and dopamine beta-hydroxylase activity in the genetically epilepsy-prone rat
3. Electroshock- and pentylenetetrazol-induced seizures in genetically epilepsy-prone rats (GEPRs): Differences in threshold and pattern
4. Brain regional amino acid levels in seizure susceptible rats: Changes related to sound-induced seizures
5. Indices of noradrenergic function in the central nervous system of seizure-naive genetically epilepsyprone rats
6. Responsiveness of genetically epilepsy-prone rats to aminophylline-induced seizures and interactions with quinolones
7. Local anaesthetic actions of cocaine: Effects on excitatory and inhibitory synaptic responses in the hippocampus in vitro
8. Loss of intensity-induced inhibition in inferior colliculus neurons leads to audiogenic seizure susceptibility in behaving genetically epilepsy-prone rats
9. GABA in the inferior colliculus plays a critical role in control of audiogenic seizures
10. Developing genetically epilepsy-prone rats have an abnormal seizure response to fluorothyl
11. Effects of nitric oxide synthase inhibition with or without nitric oxide inhalation on responses to systemic cocaine administration in rats
12. Substantia nigra: Site of anticonvulsant activity mediated by gamma-aminobutyric acid
13. Protection from local anesthetic-induced convulsions by gamma-aminobutyric acid
14. Role of brain norepinephrine in audiogenic seizure in the rat
15. Abnormalities in monoamine levels in the central nervous system of the genetically epilepsy-prone rat
16. Noradrenergic and serotonergic determinants of seizure susceptibility and severity in genetically epilepsy-prone rats
17. 5 GABA(A) receptor subunits in seizure-prone and seizure-resistant rat models of temporal lobe epilepsy
18. The genetically epilepsy-prone rat: An overview of seizure-prone characteristics and responsiveness to anticonvulsant drugs
19. Responsiveness of genetically epilepsy-prone rats to intracerebroventricular morphine-induced convulsions
20. Two genetically-selected strains of rats exhibit hypersensitivity or resistance to cocaine-induced fatal arrhythmias
21. Alterations in mRNA expression of systems that regulate neurotransmitter synaptic content in seizure-naive genetically epilepsy-prone rat (GEPR): Transporter proteins and rate-limiting synthesizing enzymes for norepinephrine, dopamine and serotonin
22. Cocaine: Evidence for NMDA-, beta-carboline- and dopaminergic-mediated seizures in mice
23. Cocaine depresses GABAA current of hippocampal neurons