Effect of carbonate salts on the kinetics of acid-catalyzed dimerization of adefovir dipivoxil

Pharmaceutical Research

Volumn 17, Issue 9, 2000, Pages 1098-1103

  Yuan, L C ^a,b   Dahl, T C ^a   Oliyai, R ^a  

^a GILEAD SCIENCES   (United States)

^b Praecis Pharmaceuticals   (United States)

Author keywords

Adefovir dipivoxil; Carbonate salts; Chemical stability; Dimerization; Formaldehyde; pH modifying agent

Indexed keywords

ADEFOVIR DIPIVOXIL; CALCIUM CARBONATE; CARBONIC ACID DERIVATIVE; FORMALDEHYDE; MAGNESIUM CARBONATE; PIVALIC ACID;

ARTICLE; CONTROLLED STUDY; DIMERIZATION; DRUG BINDING; DRUG DEGRADATION; DRUG FORMULATION; DRUG SOLUBILITY; DRUG STABILITY; HYDROLYSIS; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SOLID STATE;

EID: 0033766049     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1026457729708     Document Type: Article

References (17)

1. Prodrug of phosphates, phosphonates, and phosphinates
2. Hydrolysis of pivampicillin in buffer and plasma solutions. Formation of a 4-imidazolidinone from ampicillin and formaldehyde
3. Isolation and identification of cross-links from formaldehyde-treated nucleic acids
4. Formaldehyde preferentially interstrand cross-links duplex DNA through deoxyadenosine residues at the sequences 5'-d(AT)
5. 6-benzylguanine in aqueous polyethylene glycol 400 (PEG 400) solutions: Concerns with formaldehyde in PEG 400
6. Synthesis and in vitro evaluation of a phosphonate prodrug: Bis(pivaloyloxymethyl)-9-(2-phosphonylethoxyethyl)adenine
7. Characterization of the thermal decomposition of adefovir dipivoxil in the solid state
8. Drug-excipient incompatibility studies of the dipeptide angiotensin-converting enzyme inhibitor, moexipril hydrochloride: Dry powder vs. wet granulation
9. Approaches for improving the stability of ketorolac in powder blends
10. Saturated salt solutions for maintaining specified relative humidities
11. Solubility of gaseous formaldehyde in liquid water and generation of trace standard gaseous formaldehyde
12. General acid catalysis of semicarbazone formation
13. On the mechanism of Schiff base formation and hydrolysis
14. The timing of the proton transfer process in acid-catalyzed carbonyl addition. Evidence for a pre-association mechanism for catalysis of carbinolamine formation from acetahydrazid and p-chlorobenzaldehyde
15. Mechanism of carbinolamine formation
16. Metal-ion-coordinating properties of various phosphonate derivatives, including 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA) - An adenosine monophosphate (AMP) analogue with antiviral properties