CREM, a master-switch of the transcriptional cascade in male germ cells

Journal of Endocrinological Investigation

Volumn 23, Issue 9, 2000, Pages 592-596

  De Cesare, D ^a   Fimia, G M ^a   Sassone Corsi, P ^a  

^a INSERM   (France)

Author keywords

Apoptosis; CREM; Cyclic AMP; Spermatogenesis; Transcription

Indexed keywords

ADENYLATE CYCLASE; CALCIUM; CYCLIC AMP; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; FOLLITROPIN; GROWTH FACTOR; HEAT SHOCK PROTEIN; LIM PROTEIN; TRANSCRIPTION FACTOR;

APOPTOSIS; ENZYME ACTIVATION; GERM CELL; HUMAN; HYPOTHALAMUS HYPOPHYSIS GONAD SYSTEM; MALE; MALE INFERTILITY; MEIOSIS; MOUSE MUTANT; NONHUMAN; PHOSPHORYLATION; PROTEIN EXPRESSION; REVIEW; SIGNAL TRANSDUCTION; SPERMATID; SPERMATOGENESIS; SPERMATOZOON; TRANSCRIPTION REGULATION;

EID: 0033765812     PISSN: 03914097     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03343781     Document Type: Review

References (14)

1. Transcriptional regulation by cyclic AMP
2. Transcription factors responsive to cAMP
3. CREM gene: Use of alternative DNA-binding domains generates multiple antagonists of cAMP-induced transcription
4. Signaling routes to CREM and CREB: Plasticity in transcriptional activation
5. Analysis of the cAMP-dependent protein kinase system using molecular genetic approaches
6. Transcriptional regulation by cyclic AMP-responsive factors
7. Developmental switch of CREM function during spermatogenesis: From antagonist to activator
8. Induction of CREM activator proteins in spermatids: Down-stream targets and implications for haploid germ cell differentiation
9. Pituitary hormone FSH directs the CREM functional switch during spermatogenesis
10. Spermiogenesis deficiency and germ-cell apoptosis in CREM-mutant mice
11. Severe impairment of spermatogenesis in mice lacking the CREM gene
12. CBP-independent activation of CREM and CREB by the LIM-only protein ACT
13. The LIM domain: A new structural motif found in zinc-finger-like proteins
14. Mechanisms of activation by CREB and CREM: Phosphorylation, CBP, and a novel coactivator, ACT