The factor VII-platelet interplay: Effectiveness of recombinant factor VIIa in the treatment of bleeding in severe thrombocytopathia

Seminars in Thrombosis and Hemostasis

Volumn 26, Issue 4, 2000, Pages 373-377

  Monroe, D M ^a   Hoffman, M ^a   Allen, G A ^a   Roberts, H R ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Bernard Soulier syndrome; Factor VIIa; Glanzmann's thrombasthenia; Thrombin generation; Thrombocytopathia

Indexed keywords

BLOOD CLOTTING FACTOR 5; BLOOD CLOTTING FACTOR 9; FIBRIN; FIBRINOGEN RECEPTOR; GLYCOPROTEIN IB; RECOMBINANT BLOOD CLOTTING FACTOR 7A; VON WILLEBRAND FACTOR;

BERNARD SOULIER DISEASE; BLEEDING; DRUG MECHANISM; DRUG MEGADOSE; GLANZMANN DISEASE; HEMOPHILIA; HEMOSTASIS; HUMAN; PRIORITY JOURNAL; REVIEW; THROMBOCYTE DISORDER; UREMIA;

BLOOD PLATELET DISORDERS; BLOOD PLATELETS; FACTOR VII; HEMORRHAGE; HUMANS; RECOMBINANT PROTEINS;

EID: 0033764370     PISSN: 00946176     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (14)

1. Effective treatment of severe bleeding due to acquired thrombocytopathia by single dose administration of activated recombinant factor VII
2. Treatment of a patient with Bernard-Soulier syndrome and recurrent nosebleeds with recombinant factor VIIa
3. Recombinant factor VIIa in severe uremic bleeding
4. Continuous infusion of NovoSeven® during colectomy in a Glanzmann thrombosthenia patient with anti-glycoprotein IIb-IIIa antibody
5. Use of recombinant factor VIIa and HLA matched platelets to prevent bleeding during and after major surgery in a patient with Glanzmann's thrombosthenia
6. Use of recombinant factor VIIa (NovoSeven®) for dental extraction in a patient affected by platelet-type (pseudo-) von Willebrand disease
7. Activated factor VII activates factors IX and X on the surface of activated platelets: Thoughts on the mechanism of action of high-dose activated factor VII
8. Factors IXa and Xa play distinct roles in tissue factor-dependent initiation of coagulation
9. Platelet activity of high dose factor VIIa is independent of tissue factor
10. Factor VIIa catalyzed activation of factor X independent of tissue factor: Its possible significance for control of hemophilic bleeding by infused factor VIIa
11. Studies on the activation of factor VII bound to tissue factor
12. The regulation of the factor VII-dependent coagulation pathway: Rationale for the effectiveness of recombinant factor VII in refractory bleeding disorders
13. Clinical experience with recombinant factor VIIa in patients with thrombocytopenia
14. A possible mechanism of activated factor VII independent of tissue factor