Transcriptional regulation of the Hedgehog effector CI by the zinc-finger gene combgap

Development

Volumn 127, Issue 19, 2000, Pages 4095-4103

  Campbell, G L ^a   Tomlinson, A ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Combgap; Cubitus interruptus; Drosophila; Gli; Hedgehog; Imaginal discs; Zinc finger

Indexed keywords

COMBGAP PROTEIN; CUBITUS INTERRUPTUS PROTEIN; DNA BINDING PROTEIN; GLI PROTEIN; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

ANTERIOR POSTERIOR AXIS; ARTICLE; CELL FATE; CELL SPECIFICITY; CONTROLLED STUDY; DROSOPHILA; EMBRYO; FORELIMB; GENE EXPRESSION REGULATION; GENE MUTATION; GENE REPRESSION; GENE SEQUENCE; GENE TARGETING; GROWTH REGULATION; LIMB DEVELOPMENT; LIMB MALFORMATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

ALLELES; AMINO ACID SEQUENCE; ANIMALS; BODY PATTERNING; DNA TRANSPOSABLE ELEMENTS; DNA-BINDING PROTEINS; DROSOPHILA; DROSOPHILA PROTEINS; EXTREMITIES; GENE EXPRESSION REGULATION; GENES, INSECT; HOMEODOMAIN PROTEINS; INSECT PROTEINS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, INSERTIONAL; MUTATION; PHENOTYPE; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; ZINC FINGERS;

ANIMALIA; CUBITUS; CUBITUS INTERRUPTUS; ERINACEIDAE; HEXAPODA;

EID: 0033763116     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal
2. Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins
3. Ci: A complex transducer of the hedgehog signal
4. Proteolysis that is inhibited by Hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor
5. Compartment boundaries and the control of Drosophila limb pattern by hedgehog protein
6. Engrailed expression in the anterior lineage compartment of the developing wing blade of Drosophila
7. Compartments and appendage development in Drosophila
8. The specification of neuronal identity by graded Sonic Hedgehog signalling
9. Initiation of the proximodistal axis in insect legs
10. The roles of the homeobox genes aristaless and Distal-less in patterning the legs and wings of Drosophila
11. Targeted expression of the signaling molecule decapentaplegic induces pattern duplications and growth alterations in Drosophila wings
12. Nuclear trafficking of Cubitus interruptus in the transcriptional regulation of Hedgehog target gene expression
13. Mutants of cubitus interruptus that are independent of PKA regulation are independent of hedgehog signaling
14. Compartments and polyclones in insect development
15. Opposing transcriptional outputs of Hedgehog signaling and engrailed control compartmental cell sorting at the Drosophila A/P boundary
16. Cell interaction between compartments establishes the proximal-distal axis of Drosophila legs
17. Sending and receiving the hedgehog signal: Control by the Drosophila Gli protein cubitus interruptus
18. Repression of ci-D in posterior compartments of Drosophila by engrailed
19. The world according to hedgehog
20. Drosophila cubitus interruptus forms a negative feedback loop with patched and regulates expression of Hedgehog target genes
21. Some observation on the interaction of comb-gap with Hairless, engrailed and alleles at the cubitus interruptus locus in Drosophila melanogaster
22. Mutant effects in multiple heterozygotes of recessive venation mutants in Drosophila melanogaster
23. Pattern formation. Hedgehog points the way
24. The patched gene in development and cancer
25. Role of the Drosophila patched gene in positional signalling
26. The engrailed locus of Drosophila: In situ localization of transcripts reveals compartment-specific expression
27. Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus
28. Requirements for hedgehog, a segmental polarity gene, in patterning larval and adult cuticle of Drosophila
29. Hedgehog signal transduction: From flies to vertebrates
30. Cloning and characterization of the segment polarity gene cubitus interruptus Dominant of Drosophila
31. Sonic hedgehog mediates the polarizing activity of the ZPA
32. Gli proteins and Hedgehog signalling
33. Drawing a stripe in Drosophila imaginal disks: Negative regulation of decapentaplegic and patched expression by engrailed
34. Analysis of cubitus interruptus regulation in Drosophila embryos and imaginal disks
35. Mutations that alter the timing and pattern of cubitus interruptus gene expression in Drosophila melanogaster
36. The Berkeley Drosophila genome project gene disruption project. Single P-element insertions mutating 25% of vital Drosophila genes
37. A Hedgehog activity gradient contributes to AP axial patterning of the Drosophila wing
38. Creating a Drosophila wing de novo, the role of engrailed, and the compartment border hypothesis
39. Smoothened encodes a receptor-like serpentine protein required for hedgehog signalling
40. The interactions of some morphogenetic genes in Drosophila melanogaster
41. Protein kinase A antagonizes Hedgehog signaling by regulating both the activator and repressor forms of cubitus interruptus
42. Sequential organizion activities of engrailed, hedgehog and decapentaplegic in the Drosophila wing