Pentosanpolysulfate inhibits mast cell histamine secretion and intracellular calcium ion levels: An alternative explanation of its beneficial effect in interstitial cystitis

Journal of Urology

Volumn 164, Issue 6, 2000, Pages 2119-2125

  Chiang, George ^a,b,c   Patra, Phani ^a,b   Letourneau, Richard ^a,b   Jeudy, Sheila ^a,b   Boucher, William ^a,b   Green, Marlon ^a,b   Sant, Grannum R ^a,b,d   Theoharides, Theoharis C ^a,b  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TUFTS MEDICAL CENTER   (United States)

^c American Urological Association   (United States)

^d Alza Pharmaceuticals   (United States)

Author keywords

Cystitis, interstitial; Heparin; Histamine; Pentosan sulfuric polyester; Proteoglycans

Indexed keywords

BRADYKININ; CALCIUM ION; CROMOGLYCATE DISODIUM; GLYCOSAMINOGLYCAN; HISTAMINE; IMMUNOGLOBULIN E; PENTOSAN POLYSULFATE; PEPTIDE DERIVATIVE; POLYSACCHARIDE SULFATE; SUBSTANCE P;

ANIMAL CELL; ANTIGEN SPECIFICITY; ARTICLE; BLADDER MUCOSA; BONE MARROW; CALCIUM CELL LEVEL; CELL SECRETION; CELL STIMULATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; HISTAMINE RELEASE; INFLAMMATION; INTERSTITIAL CYSTITIS; MALE; MAST CELL; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; RAT; TACHYPHYLAXIS; VASODILATATION;

EID: 0033762810     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-5347(05)66981-9     Document Type: Article

References (51)

1. Interstitial cystitis: A neuroimmunoendocrine disorder
2. Bladder-surface glycosaminoglycans: An efficient mechanism of environmental adaptation
3. The role of the mast cell in interstitial cystitis
4. Mast cell: A neuroimmunoendocrine master player
5. The mast cell: A versatile effector cell for a challenging world
6. Direct innervation of neurolipomastocytes in the rabbit and rat cerebral artery wall
7. Mast cells: The neuroimmune connection
8. Morphological and functional demonstration of rat dura mast cell-neuron interactions in vitro and in vivo
9. Mast cells, neuropeptides and inflammation
10. Neuropeptides, mast cells and allergy: Novel mechanisms and therapeutic possibilities
11. Trigeminal sensory fiber stimulation induces morphologic changes reflecting secretion in rat dura mast cells
12. Stress-induced bladder mast cell activation: Implications for interstitial cystitis
13. The natural history of interstitial cystitis: A survey of 374 patients
14. Mucosal mast cells. II: Effects of anti-allergic compounds on histamine secretion by isolated intestinal mast cells
15. IgE-mediated release of leukotriene C4, chondroitin sulfate E proteoglycan, beta-hexosaminidase, and histamine from cultured bone marrow-derived mouse mast cells
16. Treatment of interstitial cystitis with intravesical heparin
17. Differential release of serotonin and histamine from mast cells
18. Hydroxyzine inhibits neurogenic bladder mast cell activation
19. 3H]serotonin
20. Homology of the rat basophilic leukemia cell and the rat mucosal mast cell
21. Antiallergic drug cromolyn may inhibit histamine secretion by regulating phosphorylation of a mast cell protein
22. Immunologic release of heparin from purified rat peritoneal mast cells
23. Inhibitory effect of heparin upon histamine release by trypsin, antigen and proteose
24. Heparin inhibits the immediate response to antigen in the skin and lungs of allergic subjects
25. Protective effect of heparin on immunologically induced tracheal smooth muscle contraction in vitro
26. Immunologic mast cell mediated responses and histamine release are attenuated by heparin
27. Successful treatment of interstitial cystitis with sodium pentosanpolysulfate
28. A placebo-controlled study of intravesical pentosanpolysulfate for the treatment of interstitial cystitis
29. Results of treatment of refractory interstitial cystitis with intravesical hyahironic acid
30. Heparin inhibits inositol-triphosphate-induced calcium release from permeabilized rat liver cells
31. Epithelial dysfunction in nonbacterial cystitis (interstitial cystitis)
32. Bladder permeability in interstitial cystitis is similar to that of normal volunteers: Direct measurement by transvesical absorption of 99mtechnetium-diethylenetriaminepentaacetic acid
33. Urinary chondroitin sulfates, heparan sulfate and total sulfated glycosaminoglycans in interstitial cystitis
34. Distinctive ultrastructural pathology of nonulcerative interstitial cystitis
35. Interstitial cystitis: Increased sympathetic innervation and related neuropeptide synthesis
36. Interstitial cystitis: Correlation with nerve fibres, mast cells and histamine
37. Nerve fibre proliferation in interstitial cystitis
38. Increased number of substance P positive nerve fibers in interstitial cystitis
39. Intragranular activation of bladder mast cells and their association with nerve processes in interstitial cystitis
40. Mast cell and substance P-positive nerve involvement in a patient with both irritable bowel syndrome and interstitial cystitis
41. Irritable bowel, irritable body, or irritable brain?
42. Neurotensin mediates rat bladder mast cell degranulation triggered by acute psychological stress
43. Acute stress causes mucin release from rat colon: Role of corticotropin releasing factor and mast cells
44. Inhibitory effects of sialic acid- or N-Acetylghicosamine-specific lectins on histamine release induced by compound 48/80, bradykinin and a polyethylenimine in rat peritoneal mast cells
45. Chondroitin sulfate as a regulator of neuronal patterning in the retina
46. Heparin oligosaccharides bind L and P-selectin and inhibit acute inflammation
47. Human dermal mast cells contain and release tumor necrosis factor α, which induces endothelial leukocyte adhesion molecule 1
48. CD48 binds to heparin sulfate on the surface of epithelial cells
49. Terminal ileal mucosal mast cells in irritable bowel syndrome
50. A deficit of chondroitin sulfate proteoglycans on the bladder urothelium in interstitial cystitis
51. Decreased incorporation of 14C-glucosamine relative to 3H-N-acetyl glucosamine in the intestinal mucosa of patients with inflammatory bowel disease