Aldosterone (mineralocorticoid) equivalent to prednisolone (glucocorticoid) in reversing hearing loss in MRL/MpJ-Fas(lpr) autoimmune mice

Laryngoscope

Volumn 110, Issue 11, 2000, Pages 1902-1906

  Trune, Dennis R ^a,b   Kempton, J Beth ^a   Kessi, Monica ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Adrenocorticosteroid; Aldosterone; Autoimmune hearing loss; MRL MpJ Fas(lpr) autoimmune mice; Prednisolone

Indexed keywords

ALDOSTERONE; CORTICOSTEROID; GLUCOCORTICOID; MINERALOCORTICOID; PREDNISOLONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUDIOMETRY; AUDITORY RESPONSE; AUTOIMMUNE DISEASE; BRAIN STEM RESPONSE; COCHLEA; CONTROLLED STUDY; CORTICOSTEROID THERAPY; DRUG EFFECT; HEARING LOSS; MOUSE; NONHUMAN; PRIORITY JOURNAL; STRIA VASCULARIS; TREATMENT OUTCOME;

EID: 0033762268     PISSN: 0023852X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005537-200011000-00025     Document Type: Article

References (20)

1. Corticosteroid pharmacokinetics in the inner ear fluids: An animal study followed by clinical application
2. Breakdown of stria vascularis blood-labyrinth barrier in C3H/lpr autoimmune disease mice
3. Strial dysfunction in the MRL-Fas(lpr) mouse
4. Localization and regulation by steroids of the α, β, and subunits of the amiloride-sensitive Na+ channel in colon, lung, and kidney
5. Glucocorticosteroids increase sodium transport in middle ear epithelium
6. Aldosterone regulation of gene transcription leading to control of ion transport
7. Steroid responsive cochlear dysfunction in the MRL/lpr autoimmune mouse
8. Steroid therapy improves cochlear function in the C3H.MRL-Fas(lpr) autoimmune mouse
9. Steroid treatment in young MRL.MpJ-Fas(lpr) autoimmune mice prevents cochlear dysfunction
10. Inner ear DNA receptors in MRL/lpr autoimmune mice: Potential 30 and 70 kilodalton link between autoimmune disease and hearing loss
11. Pharmacological studies of antigen-induced arthritis in BALB/c mice, I: Characterization of the arthritis and the effect of steroidal and non-steroidal anti-inflammatory agents
12. Maintenance of the synthesis of large proteoglycans in anatomically intact murine articular cartilage by steroids and insulin-like growth factor I
13. Adrenalectomy, corticosteroid replacement and their importance for drug-induced memory-enhancement in mice
14. Cryoembedding and sectioning of cochleas for immunocytochemistry and in situ hybridization
15. Cochlear immunoglobulin in the C3H/lpr mouse model for autoimmune hearing loss
16. The delayed effects of ethacrynic acid on the stria vascularis of the guinea pig
17. Aldosterone and prednisolone control of cochlear function in MRL/MpJ-Fas(lpr) autoimmune mice
18. Response of the stria vascularis to corticosteroids
19. Pharmacological and functional characterization of human mineralocorticoid and glucocorticoid receptor ligands
20. Effects of immunosuppression on the development of cochlear disease in the MRL-Fas(lpr) mouse