Synchronized release of sulpiride and sodium decanoate from HPMC matrices: A rational approach to enhance sulpiride absorption in the rat intestine

Pharmaceutical Research

Volumn 17, Issue 9, 2000, Pages 1071-1076

  Baluom, M ^a   Friedman, M ^a,b   Assaf, P ^a   Haj Yehia, A I ^a,b   Rubinstein, A ^a,b  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b David R Bloom Center for Pharmacy   (Israel)

Author keywords

Hydroxypropyl methylcellulose (HPMC) matrices; Intestinal absorption enhancement; Rat; Sodium decanoate (SD); Sulpiride; Synchronized release

Indexed keywords

DECANOATE SODIUM; DECANOIC ACID DERIVATIVE; SODIUM DERIVATIVE; SULPIRIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; INTESTINE ABSORPTION; NONHUMAN; PRIORITY JOURNAL; RAT; TABLET;

EID: 0033762244     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1026449527891     Document Type: Article

References (25)

1. New mucosal dosage form of insulin
2. Enteral administration of insulin in the rat
3. Effect of aprotinin on the rectal delivery of insulin
4. Improving the oral bioavailability of sulpiride by sodium oleate in rabbits
5. Modification of intestinal absorption of drugs by lipoidal adjuvants
6. Absorption enhancers
7. Absorption enhancement of captopril in the rat colon as a putative method for capropril delivery by extended release formulations
8. Oral solid controlled release dosage forms: Role of GI-mechanical destructive forces and colonic release in drug absorption under fasted and fed conditions in humans
9. Integration of secretory and absorptive function
10. The importance of intestinal residence time of absorption enhancer on drug absorption and implication on formulative considerations
11. Absolute bioavailability, rate of absorption and dose proportionality of sulpiride in humans
12. Improving the oral bioavailability of sulpiride by a gastric-retained form in rabbits
13. Gastrointestinal absorption of sulpiride in the rat
14. Physiological mechanism for enhancement of paracellular drug transport
15. Sodium caprate elicits dilatation in human intestinal tight junctions and enhances drug absorption by the paracellular route
16. The Sabra rat: Definition of a laboratory animal
17. Mechanism of absorption enhancement and tight junction regulation
18. Rate-controlled absorption enhancement of rectally administered cefazolin in rats by a glyceride mixture (MGK)
19. Absorption enhancement of rectally infused cefoxitin sodium by medium-chain fatty acids in concious rats: Concentration-effect relationship
20. Oral administration of insulin as poly-(vinyl alcohol)-gel spheres in diabetic rats
21. Regulation of immediate and long term effects of the absorption enhancer sodium caprate in human intestinal epithelial (CACO-2) cells
22. Analysis of the swelling and release mechanisms from drug delivery systems with emphasis on drug solubility and water transport
23. The effect of Eudragit RL-100 on the mechanical and mucoadhesion properties of polycarbophil dosage forms
24. Pharmacokinetic analysis of the absorption enhancing action of decanoic acid and its derivatives in rats
25. Estimation of agitation intestity in the GI tract in humans and dogs based on in vitro/in vivo correlation