New short peptide substrates of endothelin-converting enzyme and characterization of the enzyme

Journal of Cardiovascular Pharmacology

Volumn 36, Issue 5 SUPPL. 1, 2000, Pages

  Letourneau, M ^a   Roby, P ^a   Tremblay, F ^a   Carette, J ^a   Fournier, A ^a  

^a INRS INSTITUT ARMAND FRAPPIER   (Canada)

Author keywords

Big endothelin; ECE substrate; Endothelin (ET); Endothelin converting enzyme (ECE)

Indexed keywords

BIG ENDOTHELIN 1; ENDOTHELIN; ENDOTHELIN CONVERTING ENZYME;

AMINO ACID SEQUENCE; ANIMAL TISSUE; ARTICLE; ENZYME ANALYSIS; ENZYME STRUCTURE; ENZYME SUBSTRATE; HYDROLYSIS; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL;

EID: 0033761815     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-200036001-00073     Document Type: Article

References (5)

1. Phosphoramidon-sensitive endothelin-converting enzyme in vascular endothelial cells converts big endothelin-1 and big endothelin-3 to their mature form
2. Big endothelin-1 structure important for specific processing by endothelin-converting enzyme of bovine endothelial cells
3. D-Val22 containing human big endothelin-1 analog, [D-val22] big ET-1 [16-38], inhibits the endothelin converting enzyme
4. [Phe22]-big endothelin-1 [19-37]: A new and potent inhibitor of the endothelin-converting enzyme
5. ECE-1: A membrane-bound metalloprotease that catalyses the proteolytic activation of big-endothelin-1