Development of anti-influenza drugs: II. Improvement of oral and intranasal absorption and the anti-influenza activity of Stachyflin derivatives

Journal of Pharmacy and Pharmacology

Volumn 52, Issue 10, 2000, Pages 1247-1255

  Yoshimoto, J ^a   Yagi, S ^a   Ono, J ^a   Sugita, K ^a   Hattori, N ^a   Fujioka, T ^a   Fujiwara, T ^a   Sugimoto, H ^a   Hashimoto, N ^b  

^a SHIONOGI AND CO LTD   (Japan)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; HYDROXYPROPYLMETHYLCELLULOSE; ISOINDOLE DERIVATIVE; MACROGOL 400; MACROGOL 4000; STACHYFLIN; STACHYFLIN DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG MECHANISM; DRUG SCREENING; FERRET; FEVER; GROWTH INHIBITION; IC 50; IN VIVO STUDY; INFLUENZA; INFLUENZA VIRUS; MALE; MOUSE; NONHUMAN; NOSE CAVITY; RAT; VIRUS REPLICATION;

EID: 0033760881     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357001777225     Document Type: Article

References (18)

1. Effect of rivabilin on HeLa cells expressing E. coli xanthine guanine phosphoribosyl transferase
2. Genetic composition and virulence of influenza virus: Differences in facets of virulence in ferrets between two pairs of recombinants with RNA segments of the same parental origin
3. Drug absorption through mucosal membranes. Effect of mucosal route and penetrant hydrophilicity
4. Absorption of polyethylene glycols 600 through 2000: The molecular weight dependence of gastrointestinal and nasal absorption
5. Di-iodo-L-tyrosine labelled dextrans as molecular size markers of nasal absorption in the rat
6. Biochemistry and clinical applications of ribavilin
7. In vivo anti-influenza virus activity of a zinc finger peptide
8. Analysis of structural requirements for the absorption of drugs and macromolecules from the nasal cavity
9. Influenza virus M2 protein has ion channel activity
10. Functional reconstitution in lipid vesicles of influenza virus M2 protein expressed by baculovirus: Evidence for proton transfer activity
11. Synergetic anti-influenza virus A (H1N1) activities of PM-523 (polyoxometalate) and ribavirin in vitro and in vivo
12. An improved MTT assay
13. Lessons for human influenza from pathogenicity studies with ferrets
14. Characterization of an avian influenza A (H5N1) virus isolated from a child with a fatal respiratory illness
15. First total synthesis of (±)-Stachyflin
16. Localisation von lipiden und hydrolasen in der regio respiratoria der normalen nasenschleimhaut des menschen
17. Development of anti-influenza drugs: I. Improvement of oral absorption and in vivo anti-influenza activity of stachyflin and its derivative
18. Identification of a novel HA conformation change inhibitor of human influenza virus