A transgenic strategy for analysis of the function of the endothelin-B-receptor

Journal of Cardiovascular Pharmacology

Volumn 36, Issue 5 SUPPL. 1, 2000, Pages

  Bagnall, A ^a   Webb, D ^a   Kotelevtsev, Y ^a  

^a WESTERN GENERAL HOSPITAL   (United Kingdom)

Author keywords

Cre recombinase; Endothelin (ET); ET(B) receptor; Knockout (KO); Transgenic

Indexed keywords

ENDOTHELIN B RECEPTOR;

ARTICLE; BLOOD PRESSURE REGULATION; CELL TYPE; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RECEPTOR INTRINSIC ACTIVITY; TRANSGENE;

EID: 0033755999     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Selective antagonism of endothelin ET(A) or ET(B) receptor in renal hemodynamics and function of deoxycorticosterone acetate-salt-induced hypertensive rats
2. Different contributions of endothelin-A and endothelin-B receptors in the pathogenesis of deoxycorticosterone acetate-salt-induced hypertension in rats
3. Comparison of the effects of selective endothelin ETA and ETB receptor antagonists in congestive heart failure
4. Presence of non-selective type of endothelin receptor on vascular endothelium and its linkage to vasodilation
5. Sarafotoxin S6c: An agonist which distinguishes between endothelin receptor subtypes
6. Venous smooth muscle contains vasoconstrictor ETB-like receptors
7. Endothelin ETA and ETB receptors mediate vascular smooth muscle contraction
8. Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice
9. Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons
10. A missense mutation of the endothelin receptor B gene in multigenic Hirschsprung's disease
11. Mutation of the endothelin-receptor B gene in the Waardenburg-Hirschsprung disease
12. Interaction of the bacteriophage P1 recombinase Cre with the recombining site loxP
13. Uniform vascular-endothelial-cell-specific gene expression in both embryonic and adult transgenic mice
14. Elevation of blood pressure by genetic and pharmacological disruption of the ETB receptor in mice
15. Elevated blood pressure and craniofacial abnormalities in mice deficient in endothelin-1
16. Impaired ventilatory responses to hypoxia and hypercapnia in mutant mice deficient in endothelin-1
17. Null mutation of endothelin receptor type B gene in spotting lethal rats causes aganglionic megacolon and white coat color
18. Transgenic expression of the endothelin-B receptor prevents congenital intestinal aganglionosis in a rat model of Hirschsprung disease
19. Salt-sensitive hypertension in endothelin-B receptor-deficient rats