Evidence for downregulation of the endothelin-B-receptor by the use of fluorescent endothelin-1 and a fusion protein consisting of the endothelin-B-receptor and the green fluorescent protein

Journal of Cardiovascular Pharmacology

Volumn 36, Issue 5 SUPPL. 1, 2000, Pages

  Oksche, A ^a   Boese, G ^a   Horstmeyer, A ^a   Papsdorf, G ^a   Furkert, J ^a   Beyermann, M ^a   Bienert, M ^a   Rosenthal, W ^a  

^a LEIBNIZ INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE   (Germany)

Author keywords

Fluorescence microscopy; G protein coupled receptor; Green fluorescent protein (GFP); Lysosome

Indexed keywords

CYANINE DYE; ENDOTHELIN 1; ENDOTHELIN B RECEPTOR; GREEN FLUORESCENT PROTEIN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); HYBRID PROTEIN;

ANIMAL CELL; ARTICLE; BINDING SITE; CELL STRAIN; CONTROLLED STUDY; DOWN REGULATION; INTERNALIZATION; LASER MICROSCOPY; NONHUMAN; PRIORITY JOURNAL;

EID: 0033755995     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-200036001-00036     Document Type: Article

References (9)

1. Both ETA and ETB receptors mediate contraction to endothelin-1 in human blood vessels
2. Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor
3. Elevation of blood pressure by genetic and pharmacological disruption of the ETB receptor in mice
4. Vasodilator activity of endothelin-1 and endothelin-3: Rapid development of cross-tachyphylaxis and dependence on the rate of endothelin administration
5. Endothelin-induced endocytosis of cell surface ETA receptors. Endothelin remains intact and bound to the ETA receptor
6. Receptor externalization determines sustained contractile responses to endothelin-1 in the rat aorta
7. Folding and cell surface expression of the vasopressin V2 receptor: Requirement of the intracellular C-terminus
8. Palmitoylation of human endothelin B. Its critical role in G protein coupling and a differential requirement for the cytoplasmic tail by G protein subtypes
9. A novel subtype of endothelin receptors