Cimetidine (Tagamet) is a reproductive toxicant in male rats affecting peritubular cells

Biology of Reproduction

Volumn 63, Issue 5, 2000, Pages 1403-1412

  Franca, L R ^a   Leal, M C ^a   Sasso Cerri, E ^a   Vasconcelos, A ^a   Debeljuk, L ^a   Russell, L D ^a  

^a SOUTHERN ILLINOIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Gametogenesis; Spermatogenesis; Testes

Indexed keywords

CIMETIDINE; FOLLITROPIN; HISTAMINE H2 RECEPTOR ANTAGONIST; TESTOSTERONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BASEMENT MEMBRANE; CELL DEATH; CONTROLLED STUDY; FOLLITROPIN BLOOD LEVEL; GERM CELL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REPRODUCTIVE TOXICITY; SEMINIFEROUS TUBULE; SMOOTH MUSCLE FIBER; SPERMATOGENESIS; TESTOSTERONE BLOOD LEVEL;

ANIMALIA; MYOIDEA;

EID: 0033755955     PISSN: 00063363     EISSN: None     Source Type: Journal    
DOI: 10.1095/biolreprod63.5.1403     Document Type: Article

References (41)

1. Cimetidine is and antiandrogen in the rat
2. Maintenance of spermatogenesis in rats with intratesticular implants containing testosterone or dihydrotestosterone (DHT)
3. Studies in testicular function. I. Quantitative effects of FSH, LH, testosterone and dihydrotestosterone on restoration and maintenance of spermatogenesis in the hypophysectomized rat
4. Effects of testosterone and dihydrotestosterone on spermatogenesis, rete testis fluid, and peripheral androgen levels in hypopysectomized rats
5. Can spermatogenesis be maintained quantitatively in intact adult rats with exogenously administered testosterone?
6. Inhibition of 5a-reductase activity impairs the testosterone-dependent restoration of spermiogenesis in adult rats
7. Histamine, bradykinin, and their antagonists
8. Perfusion of the rat testis through the heart using heparin
9. Building a testis
10. The acute and long term effect of the H2-receptor antagonists cimetidine and ranitisine on the pituitary-gonadal axis in men
11. Degeneration of germ cells in normal, hypophysectomized and hormone treated hypophysectomized rats
12. Pre-and neonatal exposure to cimetidine but not ranitidine adversely affects adult sexual functioning of male rats
13. In vivo studies on the antiandrogenic effects of cimetidine versus cyproterone acetate in rats
14. A two-year study with cimetidine in the rat: Assessment for chronic toxicity and carcinogenicity
15. Influence of prenatal exposure to cimetidine and alcohol on selected morphological parameters of sexual differentiation: A preliminary report
16. Antiprostatic effect of cimetidine
17. Some effects of cimetidine on the reproductive organs of the rat
18. Immunohistochemical localization of androgen receptors in the rat testis: Evidence for stage-dependent expression and regulation by androgens
19. Glucocorticoid receptor distribution in rat testis during postnatal development and effects of dexamethasone on immature peritubular cells in vitro
20. Development of secondary sex characteristics in male rats after fetal and perinatal cimetidine exposure
21. Effect of H2-receptor antagonists, cimetidine and ranitidine on reproductive functions in male mice
22. Optimal replication for histometric analyses of testicular function in rats or rabbits
23. Novel aspect of Lindane testicular toxicity: In vitro effects on peritubular myoid cells
24. Drug-induced alterations in rat peritubular cell cytoskeleton result in proteoglycan synthesis modifications. Comparison with some intracellular signaling pathways
25. Comparative observations on intertubular lymphatics and the organization of the interstitial tissue of the mammalian testis
26. Contractile elements in the limiting membrane of the seminiferous tubules of the rat
27. Contractility of the seminferous tubules of the postnatal rat testis and its response to oxytocin
28. Sertoli cell-peritubular myoid cell interactions
29. Basement membrane gene expression by Sertoli and peritubular myoid cells in vitro in the rat
30. Golden hamster myoid cells during active and inactive states of spermatogenesis: Correlation of testosterone levels with structure
31. Immune complex orchitis in vasectomized rabbits
32. Structural and functional abnormality of ectopic testes in rats
33. Altered basement membrane synthesis in the testis after injury
34. Hormonal regulation of spermatogenesis in the hypophysectomized rat: Quantitation of germ cell population and effect of elimination of residual testosterone after long-term hypophysectomy
35. Appearance of as-mooth muscle actin in peritubular cells of monkey testes is induced by androgens, modulated by follicle-stimulating hormone, and maintained after hormonal withdrawal
36. Changes in the testicular microvasculature during photoperiod-related seasonal transition from reproductive quiescence to reproductive activity in the adult golden hamster
37. Morphometric studies on hamster testes in gonadally active and inactive states: Light microscope findings
38. Developing testicular microvasculature in the golden hamster, Mesocricetus auratus: A model for angiogenesis under physiological conditions
39. Regulation of Spermatogenesis. 2nd ed
40. Effect of cimetidine on gonadal function in man