Glycoprotein Ib/IX complex is the target in rifampicin-induced immune thrombocytopenia

British Journal of Haematology

Volumn 110, Issue 4, 2000, Pages 907-910

  Pereira, Jaime ^a   Hidalgo, Patricia ^a   Ocqueteau, Mauricio ^a   Blacutt, Marcelo ^b   Marchesse, Miguel ^b   Nien, Yih ^b   Letelier, Luz ^b   Mezzano, Diego ^a  

^a PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

^b HOSPITAL DR SÓTERO DEL RÍO   (Chile)

Author keywords

Drug dependent; Drug induced; Glycoprotein Ib IX; Immune mediated; Thrombocytopenia

Indexed keywords

GLYCOPROTEIN GPIV; GLYCOPROTEIN IB; GLYCOPROTEIN IB IX COMPLEX; IMMUNOGLOBULIN G ANTIBODY; PREDNISONE; RIFAMPICIN; UNCLASSIFIED DRUG;

ADULT; ANTIBODY SPECIFICITY; ARTICLE; BINDING SITE; CASE REPORT; CONTROLLED STUDY; DRUG INDUCED DISEASE; DRUG INTERMITTENT THERAPY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOPRECIPITATION; MALE; PRIORITY JOURNAL; THROMBOCYTOPENIA; TUBERCULOSIS;

ADULT; ANTIBIOTICS, ANTITUBERCULAR; ANTIBODIES, MONOCLONAL; ANTIGEN-ANTIBODY REACTIONS; BLOOD PLATELETS; EPITOPE MAPPING; EPITOPES; FLOW CYTOMETRY; HUMANS; IMMUNOGLOBULIN G; MALE; PLATELET GLYCOPROTEIN GPIB-IX COMPLEX; PRECIPITIN TESTS; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC; RIFAMPIN;

EID: 0033754949     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2000.02299.x     Document Type: Article

References (12)

1. Rifampicin-dependent antibodies bind a similar or identical epitope to glycoprotein IX-specific quinine-dependent antibodies
2. Characterization of the binding domains on platelet glycoprotein Ib-IX and IIb/IIIa complexes for the quinine/quinidine-dependent antibodies
3. An antibody from a patient with ranitidine-induced thrombocytopenia recognizes a site on glycoprotein IX that is a favored target for drug-induced antibodies
4. Rifampin-induced immune thrombocytopenia
5. Monoclonal antibody-specific immobilization of platelet antigens (MAIPA): A new tool for the identification of platelet-reactive antibodies
6. Thrombocytopenia: A rare but potentially serious side effect of initial daily and interrupted use of rifampicin
7. 125I-labelled antihuman IgG monoclonal antibody to quantify platelet-bound IgG
8. The glycoprotein Ib-IX complex-specific antibody SZ1 binds to a conformation-sensitive epitope on glycoprotein IX: Implications for the target antigen of quinine/quinidine-dependent autoantibodies
9. Drug-induced thrombocytopenias
10. Rifampicin-induced immune thrombocytopenia
11. Potentially serious side-effects of high-dose twice-weekly rifampicin
12. Thrombocytopenia caused by hypersensitivity to rifampicin in intermittent high doses