A single genetic determinant that prevents sex reversal in C57BL-Y(POS) congenic mice

Biochemical Genetics

Volumn 38, Issue 5-6, 2000, Pages 119-137

  Whitney Iii, J Barry ^a   Mills, Thomas M ^a   Lewis, Ronald W ^a   Wartell, Roger ^b   Abney, Tom O ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

^b GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Major urinary protein; Mouse genetics; Sex determination; Sex reversal; Sry gene; Testosterone; Y chromosome

Indexed keywords

M PROTEIN; TESTOSTERONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONGENIC STRAIN; CONTROLLED STUDY; DNA DETERMINATION; FEMALE; GENE ACTIVATION; GENETIC ANALYSIS; GONAD; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; PHENOTYPE; PROTEIN URINE LEVEL; SEX DETERMINATION; SEX TRANSFORMATION; TESTOSTERONE BLOOD LEVEL; Y CHROMOSOME;

ALPHA-GLOBULINS; ANIMALS; DNA-BINDING PROTEINS; FEMALE; MALE; MICE; MICE, CONGENIC; MICE, INBRED C57BL; NUCLEAR PROTEINS; ORGAN SIZE; OVARY; PHENOTYPE; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; PROTEINS; SEX DETERMINATION (GENETICS); SEX REVERSAL, GONADAL; SEX-DETERMINING REGION Y PROTEIN; TESTIS; TESTOSTERONE; TRANSCRIPTION FACTORS; X CHROMOSOME; Y CHROMOSOME;

ANIMALIA; MAMMALIA; MUS; MUS MUSCULUS MUSCULUS; MUSCULUS;

EID: 0033754247     PISSN: 00062928     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. DNA sequence analysis of the Sry alleles (subgenus Mus) implicates misregulation as the cause of C57BL/6J-Y(POS) sex reversal and defines the SRY functional unit
2. Genetic evidence equating SRY and the testis-determining factor
3. The testis-determining autosomal trait, Tda-1, of C57BL/6J is determined by more than a single autosomal gene when compared with DBA/2J mice
4. Pheromone binding to two rodent urinary proteins revealed by X-ray crystallography
5. Sry requires a CAG repeat domain for male sex determination in Mus musculus
6. True hermaphroditism in a 46,XY individual, caused by a postzygotic somatic point mutation in the male gonadal sex-determining locus (SRY): Molecular genetics and histological findings in a sporadic case
7. Polymorphism of a CAG trinucleotide repeat within Sry correlates with B6. YDom sex reversal
8. Autosomal genes involved in mammalian primary sex determination
9. Sex and trinucleotide repeats
10. Inherited sex reversal in mice: Identification of a new primary sex-determining gene
11. Mus poschiavinus Y chromosome in the C57BL/6 murine genome causes sex reversal
12. Sex-determining genes on mouse autosomes identified by linkage analysis of C57BL/6J-YPOS sex reversal
13. Sequence variation in the 5', putative promoter of Sry and its possible relevance to the C57BL/6J-YDOM sex reversal
14. A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes
15. Inverted repeat structure of the Sry locus in mice
16. DNA binding activity of recombinant SRY from normal males and XY females
17. Testis-determining factor and Y-linked Sex reversal
18. Mutational analysis of SRY: Nonsense and missense mutations in XY sex reversal
19. True hermaphrodites: An experimental model in the mouse
20. Oestrogen regulation of testicular androgen production during development in the rat
21. Differential, multihormonal regulation of the mouse major urinary protein gene family in the liver
22. Male development of chromosomally female mice transgenic for Sry
23. Sry interactive proteins: Implications for the mechanisms of sex determination
24. Normal onset, but prolonged expression, of Sry gene in the B6.YDOM sex-reversed mouse gonad
25. Tdy-negative XY, XXY and XYY female mice: Breeding data and synaptonemal complex analysis
26. Transcriptional coregulators in development
27. The genetic basis of murine and human sex determination: A review
28. Acceleration of puberty onset in female mice by male urinary proteins
29. Protein-bound male urinary pheromones: Differential responses according to age and gender
30. Testosterone and androstanediol production by regenerating Leydig cells in the ethylene dimethane sulphonate-treated mature rat
31. Morphological development of the mouse gonad in tda-1 XY sex reversal
32. Sequence instability and functional inactivation of murine Y chromosomes can occur on a specific genetic background
33. The Mus musculus domesticus Tdy allele acts later than the Mus musculus musculus Tdy allele: A basis for XY sex-reversal in C57BL/6-YPOS mice
34. Gene interactions in gonadal development
35. A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif
36. Delay of testicular differentiation in the B6.YDOM ovotestis demonstrated by immunocytochemical staining for mullerian inhibiting substance
37. Development and fertility of ovaries in the B6.YDOM sex-reversed female mouse
38. Normal testis determination in the mouse depends on genetic interaction of a locus on chromosome 17 and the Y chromosome
39. Hba: New genotypes
40. Alpha thalassemia (Hba(th-J))