Improving the performance of an acid-labile 4-hydroxymethyl phenoxyacetic acid (HMP) linker on resin and synphase(TM) grafted solid-supports

Journal of Peptide Science

Volumn 6, Issue 10, 2000, Pages 534-538

  Bui, Chinh T ^a   Ercole, Francesca ^a   Pham, Yen ^a   Campbell, Rhonda ^a   Rasoul, Firas A ^a   Joe Maeji, N ^a   Ede, Nicholas J ^a  

^a Mimotopes Pty Ltd   (Australia)

Author keywords

4 Hydroxymethylphenoxyacetic acid; 5 (4 Hydroxymethylphenoxy)pentanoic acid; Multipin solid support; Solid phase organic chemistry

Indexed keywords

4 HYDROXYMETHYLPHENOXYACETIC ACID; PHENOXYACETIC ACID DERIVATIVE; RESIN; UNCLASSIFIED DRUG; VALERIC ACID DERIVATIVE;

ARTICLE; CHEMICAL MODIFICATION; CHEMICAL STRUCTURE; COMPARATIVE STUDY; CONTROLLED STUDY; ESTERIFICATION; PEPTIDE SYNTHESIS; PERFORMANCE; PRIORITY JOURNAL; SOLID STATE;

BIOCHEMISTRY; GLYCOLATES; PEPTIDES; RESINS, PLANT;

EID: 0033754192     PISSN: 10752617     EISSN: None     Source Type: Journal    
DOI: 10.1002/1099-1387(200010)6:10<534::AID-PSC288>3.0.CO;2-3     Document Type: Article

References (10)

1. Acid-labile resin linkage agents for use in solid phase peptide synthesis
2. Perspective. Matrix assisted synthetic transformations: A mosaic of diverse contributions. I The pattern emerges
3. Efficiencies of reductive amination reactions on different solid supports
4. Multiple peptide synthesis on acid-labile handle derivatized polyethylene supports
5. The synthesis of a 1680 member 1,4-benzodiazepine
6. Solid-phase synthesis of protected peptide hydrazides. Preparation and application of hydroxymethyl resin and 3-(p-benzyloxyphenyl)-1,1-dimethylpropyloxycarbonylhydrazides resin
7. The combinatorial synthesis and chemical and biological evaluation of a 1,4-benzodiazepine library
8. Grafted supports used with the multipin method of peptide synthesis
9. Acetophenone-based linker for solid-phase peptide synthesis
10. Comparative study of reductive amination reaction on 5-(4-formyl-3,5-dimethoxyphenoxy)valeric acid and its monomethoxy analog using the Multipin(TM) approach