Electrical bone graft stimulation for spinal fusion: A review

Neurosurgery

Volumn 47, Issue 5, 2000, Pages 1041-1056

  Oishi, M ^a   Onesti, S T ^a   Benzel, E C ^a   Ferrara, L ^a   Fessler, R G ^a   McCormick, P C ^a   Kaiser, M G ^a   Sonntag, V K H ^a  

^a MONTEFIORE MEDICAL CENTER   (United States)

Author keywords

Electrical stimulation; Graft; Spinal fusion

Indexed keywords

BONE GRAFT; BONE GROWTH; ELECTROMAGNETIC FIELD; ELECTROSTIMULATION THERAPY; GROWTH STIMULATION; HUMAN; LUMBAR SPINE; NONHUMAN; PRIORITY JOURNAL; REVIEW; SPINE FUSION; TREATMENT INDICATION;

EID: 0033753817     PISSN: 0148396X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006123-200011000-00005     Document Type: Review

References (164)

1. Tissue interactions with nonionizing electromagnetic fields
2. Capacitively coupled electrical stimulation of bovine growth plate chondrocytes grown in pellet form
3. The effects of pulsed magnetic fields of the type used in the stimulation of fracture healing
4. Pulsed magnetic field therapy for tibial nonunion: Interim results of a double-blind trial
5. Biophysical principles affecting bone structure
6. Pulsing electromagnetic fields: A new method to modify cell behavior in calcified and noncalcified tissues
7. Beneficial effects of electromagnetic fields
8. Generation of electric potentials by bone in response to electromagnetic stress
9. Noninvasive methods for stimulating osteogenesis
10. Congenital 'pseudarthroses' of the tibia: Treatment with pulsing electromagnetic fields
11. Treatment of ununited tibial diaphyseal fractures with pulsing electromagnetic fields
12. Pulsing electromagnetic field treatment in ununited fractures and failed arthrodeses
13. Repair of non-unions by pulsing electromagnetic fields
14. Treatment of therapeutically resistant non-unions with bone grafts and pulsing electromagnetic fields
15. Effects of electrical currents on bone in vivo
16. Acceleration of fracture repair by electromagnetic fields: A surgically noninvasive method
17. Augmentation of bone repair by inductively coupled electromagnetic fields
18. A non-operative salvage of surgically-resistant pseudarthroses and non-unions by pulsing electromagnetic fields: A preliminary report
19. Prevention of disuse osteoporosis in the rat by means of pulsing electromagnetic fields
20. Modification of fracture repair with selected pulsing electromagnetic fields
21. Stimulation of partial limb regeneration in rats
22. The significance of electrically stimulated osteogenesis: More questions than answers
23. Clinical experiences with low intensity direct current stimulation of bone growth
24. Repeat lumbar spine surgery: Factors influencing outcome
25. A retrospective review of patient outcomes using internal fixation and implantable direct current stimulation in lumbar spinal fusion
26. Tissue response to exogenous electromagnetic signals
27. Do electromagnetic fields interact directly with DNA?
28. Endogenous ionic currents traverse intact and damaged bone
29. Electrical stimulation of human intertrochanteric osteotomies: Double-blind study
30. The treatment of nonunions with electricity
31. Electrical stimulation and oxygen tension
32. Oxygen tension in zones of the epiphyseal plate, the metaphysis and diaphysis: An in vitro and in vivo study in rats and rabbits
33. Oxygen tension of healing fractures in the rabbit
34. Treatment of recalcitrant non-union with a capacitively coupled electrical field
35. Cathodic oxygen consumption and electrically induced osteogenesis
36. A multicenter study of the treatment of non-union with constant direct current
37. In vitro epiphyseal growth in various constant electric fields
38. Evaluation of the use of constant direct current in the treatment of nonunion
39. Electrically induced osteogenesis: Relationship between charge, current density, and the amount of bone formed - Introduction of a new cathode concept
40. Treatment of nonunion with constant direct current
41. Direct current stimulation of non-union and congenital pseudarthrosis: Exploration of its clinical application
42. Fracture healing in the rabbit fibula when subjected to various capacitively coupled electrical fields
43. In vivo growth plate stimulation in various capacitively coupled electrical fields
44. In vitro epiphyseal plate growth in various oxygen tensions
45. In vitro growth of bovine articular cartilage chondrocytes in various capacitively coupled electrical fields
46. Evidence that pulsed electromagnetic fields inhibit coupling of adenylate cyclase by parathyroid hormone in bone cells
47. Pseudarthrosis in the lumbosacral spine
48. Electromechanical characteristics of bone under physiological moisture conditions
49. The effect of pulsing electromagnetic fields on bone metabolism in experimental disuse osteoporosis
50. A ten-year review of treatment of delayed union and nonunion with an implanted bone growth stimulator
51. Bone matrix biosynthesis in vitro: Labeling of hexosamine and collagen of normal bone
52. Embryological changes induced by weak, extremely low frequency electromagnetic fields
53. The use of electrical current stimulation in spinal fusion
54. Direct current stimulation in spinal fusion
55. Time-varying magnetic fields: Effects of orientation on chondrocyte proliferation
56. Treatment of nonuniting osteotomies with pulsating electromagnetic fields: A controlled animal experiment
57. Pulsed electromagnetic fields promote collagen production in bone marrow fibroblasts via athermal mechanisms
58. Osteoclasts and osteoblasts migrate in opposite directions in response to a constant electrical field
59. The response of skeletal tissues to pulsed magnetic fields
60. Growth factors and electromagnetic fields in bone
61. Low-amplitude, low-frequency electric field-stimulated bone cell proliferation may in part be mediated by increased IGF-II release
62. Electromagnetic stimulation of ligament healing in rabbits
63. Bioelectric potentials in bone
64. Bone reactions to varying amounts of direct current
65. Healing of medial malleolus by means of direct current: A case report
66. The cellular origin of bioelectric potentials in bone
67. Stimulation of fracture healing by direct current in the rabbit fibula
68. The response of non-traumatized bone to direct current
69. On the piezoelectric effect of bone
70. Use of electromagnetic fields in a spinal fusion: A rabbit model
71. Transcription and translation in cells exposed to extremely low frequency electromagnetic fields
72. Pulsing electromagnetic fields induce cellular transcription
73. A double-blind study of capacitively coupled electrical stimulation as an adjunct to lumbar spinal fusions
74. Pulsed electromagnetic field stimulation on posterior spinal fusions: A histological study in rats
75. Differential response to electrical stimulation: A distinction between induced osteogenesis in intact tibiae and the effect on fresh fracture defects in radii
76. On the causes and treatment of pseudarthrosis and especially that form of it sometimes called supernumerary joint
77. Studies of enhanced bone healing via electrical stimuli: Comparative effectiveness of various parameters
78. Tissue gas tension and oxygen consumption in healing bone defects
79. Treatment of non-unions by electromagnetic stimulation
80. Morphological effect of electromagnetic stimulation on the skeleton of fetal or newborn mice
81. Electromagnetic stimulation of fracture repair: Influence on healing of fresh fractures
82. Cell behaviour and DNA modification in pulsing electromagnetic fields
83. Partition of calcium, phosphate, and protein in the fluid phase aspirated at calcifying sites in the epiphyseal cartilage
84. Pulsing electromagnetic field stimulation of the in vitro growth plate
85. Electret induced callus formation in the rat
86. Effects of weak, pulsing electromagnetic fields on neural regeneration in the rat
87. The effect of pulsed electromagnetic fields on instrumented posterolateral spinal fusion and device-related stress shielding
88. Lateral mass fusion: A prospective study of a consecutive series with long-term follow-up
89. Electrical stimulation of osteogenesis in periodontal defects
90. Electrical stimulation: Current concepts and indications
91. Spine update: The use of adjunctive electrical stimulation to enhance the healing of spine fusions
92. The efficacy of direct current electrical stimulation to enhance canine spinal fusions
93. The effect of postoperative electromagnetic pulsing on canine posterior spinal fusions
94. The effect of electromagnetic pulsing on posterior lumbar spinal fusions in dogs
95. Direct current electrical bone growth stimulation for spinal fusion
96. Electrical stimulation of spinal fusions
97. Revision surgery for failed back surgery syndrome
98. A controlled prospective outcome study of implantable electrical stimulation with spinal instrumentation in a high-risk spinal fusion population
99. Results of lumbar pseudarthrosis repair
100. Experimental model for studying the effect of electric current on bone in vivo
101. The influence of electric current on bone regeneration in vivo
102. Clinical investigation of the spinal stim system
103. A comparison of in vitro cellular responses to mechanical and electrical stimulation
104. Repeat lumbar surgery: A review of patients with failure from previous lumbar surgery treated by spinal canal exploration and lumbar spinal fusion
105. Cases of ununited fracture treated by electricity
106. Inducing bone growth in vivo by pulse stimulation
107. Kinetics of channelized membrane ions in magnetic fields
108. Combined magnetic fields accelerate primary spine fusion: A double-blind, randomized, placebo controlled study
109. Biochemical pathway mediating the response of bone cells to capacitive coupling
110. Effects of low-energy electromagnetic fields (pulsed and DC) on membrane signal transduction processes in biological systems
111. Effects of electromagnetic stimuli on bone and bone cells in vitro: Inhibition of responses to parathyroid hormone by low-energy low-frequency fields
112. Magnetic healing, quackery, and the debate about the health effects of electromagnetic fields
113. Results of pulsed electromagnetic fields (PEMFs) in ununited fractures after skeletal fixation
114. Fracture healing in rats exposed to extremely low-frequency electric fields
115. Electromagnetic fields, biological systems and their connection in electromagnetic biostimulation
116. Direct current stimulation of allograft in anterior and posterior lumbar interbody fusions
117. The effect of direct current on bone
118. A randomized double-blind prospective study of the efficacy of pulsed electromagnetic fields for interbody lumbar fusions
119. Stimulation of bone formation by electrical current on spinal fusion
120. Effects of a pulsed electromagnetic field on a mixed chondroblastic tissue culture
121. Epiphyseal cartilage cAMP changes produced by electrical and mechanical perturbations
122. Effects of electric current on bone in vivo
123. Pulsing electromagnetic field therapy in nerve regeneration: An experimental study in the cat
124. Effects of pulsed extremely-low-frequency magnetic fields on skin wounds in the rat
125. Effects of electromagnetic fields in experimental fracture repair
126. Treatment of nonunions with a constant direct current: A totally implantable system
127. Electrical stimulation in the treatment of congenital pseudarthrosis of the tibia
128. Electrical bone-growth stimulation in an experimental model of delayed union
129. Experimental delayed union of the dog tibia and its use in assessing the effect of an electrical bone growth stimulator
130. Treatment of congenital pseudarthrosis of the tibia with direct current stimulation
131. Treatment of delayed union and non-union with an implanted direct current stimulator
132. A retrospective controlled study of implantable direct current stimulation in lumbar spinal fusion
133. Effects of electromagnetic field exposure on gene transcription
134. Bone changes due to pulses of direct electric microcurrent
135. Effect of capacitively coupled electric fields on an experimental model of delayed union of fracture
136. DNA synthesis in cartilage cells is stimulated by oscillating electric fields
137. Efficacy of implanted bone growth stimulation in instrumented lumbosacral spinal fusion
138. Painful internal disc derangements of the lumbar spine: Discographic diagnosis and treatment by posterior lumbar interbody fusion
139. A prospective, double-blind trial of electrical capacitive coupling in the treatment of non-union of long bones
140. Physical basis for bioelectric effects in mineralized tissues
141. Piezoelectric effect in bone
142. Treatment of failed posterior lumbar interbody fusions (PLIF) of the spine with pulsing electromagnetic fields
143. The effect of postoperative pulsing on lumbar fusion: An open trial phase study
144. PEMF, direct current and neuronal regeneration: Effect of field geometry and current density
145. Electrically stimulated bone growth in animals and man: Review of the literature
146. Experimental study on the electrical impedance of bone and the effect of direct current on the healing of fractures
147. Posterolateral lumbar-spine fusion: Analysis of the Mayo Clinic series
148. The use of implantable direct current stimulation in multilevel spinal fusion without instrumentation: A prospective clinical and radiographic evaluation with long-term follow-up
149. Pulse shape of magnetic fields influences chick embryogenesis
150. Oxygen tension and the control of bone cell metabolism
151. Stimulation of fracture healing with electromagnetic fields of extremely low frequency (EMF of ELF)
152. Effect of electric fields on growth rate of embryonic chick tibiae in vitro
153. The influence of electric potentials on plated bones
154. Accelerated healing of skin ulcers by electrotherapy
155. Electrical control of bone growth in ossicles
156. Fundamental aspects of fracture treatment
157. On the piezoelectric property of bone
158. Electrical callus and callus formation by electret
159. Dynamic callus and electric callus
160. Early effects of electrical stimulation on osteogenesis
161. A prospective, randomized study of lumbar fusion: Preliminary results
162. Electrical stimulation induces the level of TGF-β1 mRNA in osteoblastic cells by a mechanism involving calcium/calmodulin pathway
163. Electrical stimulation of bone: An overview