Effect of rifampin on plasma concentrations of mefloquine in healthy volunteers

Journal of Pharmacy and Pharmacology

Volumn 52, Issue 10, 2000, Pages 1265-1269

  Ridtitid, W ^a   Wongnawa, M ^a   Mahatthanatrakul, W ^a   Chaipol, P ^a   Sunbhanich, M ^a  

^a PRINCE OF SONGKLA UNIVERSITY   (Thailand)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLIC ACID; CYTOCHROME P450 3A4; DRUG METABOLITE; MEFLOQUINE; RIFAMPICIN;

ARTICLE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG EFFECT; DRUG EFFICACY; DRUG HALF LIFE; DRUG INHIBITION; DRUG METABOLISM; ENZYME ACTIVITY; HUMAN; HUMAN EXPERIMENT; MALARIA; MALE; NORMAL HUMAN;

EID: 0033751972     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357001777243     Document Type: Article

References (17)

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2. Food increases the bioavailability of mefloquine
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6. Long-term malaria prophylaxis with weekly mefloquine
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8. Mefloquine: A review of its antimalarial activity, pharmacokinetic properties and therapeutic efficacy
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11. Lung
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14. Pharmacokinetic drug interactions with rifampicin
15. Marked enhancement by rifampicin and lack of effect of isoniazid on the elimination of quinine in man
16. Malaria
17. Identification of human cytochrome P450 isoforms involved in the 3-hydroxylation of quinine by human liver microsomes and nine recombinant human cytochromes P450