In vivo inhibition of reduced thiol compounds from Entamoeba histolytica HK9 by phenothiazines and related tricyclic drugs

Archives of Medical Research

Volumn 31, Issue 4, 2000, Pages S12-S16

  Ondarza, Raúl N ^a,b   Iturbe, Angelica ^a   Hernández, Eva ^a   Tamayo, Elsa MarÍa ^a   Hurtado, Gerardo ^a  

^a INSTITUTO NACIONAL DE SALUD PÚBLICA   (Mexico)

^b UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

Author keywords

Entamoeba histolytica; Thiol compounds

Indexed keywords

10 PHENOTHIAZINE; CHLORPROMAZINE; CLOMIPRAMINE; DIPHENHYDRAMINE; DOXYCYCLINE; GLUTATHIONE; GLUTATHIONE REDUCTASE; KD 002; OFK 001; OFK 006; OFK 008; OFK 027; OFK 043; PHENOTHIAZINE DERIVATIVE; THIOL DERIVATIVE; TRICYCLIC ANTIDEPRESSANT AGENT; TRIFLUPROMAZINE; UNCLASSIFIED DRUG;

ARTICLE; CELL CULTURE; CHEMICAL ANALYSIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; CRITHIDIA; DRUG ACTIVITY; ENTAMOEBA HISTOLYTICA; GROWTH INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; REDUCTION; SPECIES DIFFERENCE; TROPHOZOITE; TRYPANOSOMA CRUZI;

AMEBICIDES; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENTAMOEBA HISTOLYTICA; PHENOTHIAZINES; SULFHYDRYL COMPOUNDS;

EID: 0033751002     PISSN: 01884409     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0188-4409(00)00161-2     Document Type: Article

References (5)

1. Rationally designed selective inhibitors of trypanothione reductase. Phenothiazines and related tricyclics as lead structures
2. Entamoeba histolytica: A eukaryote without glutathione metabolism
3. Isolation and purification of glutathionyl-spermidine and trypanothione from Entamoeba histolytica
4. A new medium for the axenic cultivation of Entamoeba histolytica and other Entamoeba
5. Determination of penicillamine in blood and urine by high performance liquid chromatography