5-HT inhibits spontaneous contractility of isolated sheep mesenteric lymphatics via activation of 5-HT4 receptors

Microvascular Research

Volumn 60, Issue 3, 2000, Pages 261-268

  McHale, N G ^a   Thornbury, K D ^a   Hollywood, M A ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

5 HT; Contractility; Lymphatic; Smooth muscle

Indexed keywords

2,3 DIHYDRO 2 OXO 1 BENZIMIDAZOLECARBOXYLIC ACID 6 METHOXY 3ALPHA TROPANYL ESTER; 2,3 DIHYDRO 3 ISOPROPYL 2 OXO 1 BENZIMIDAZOLECARBOXYLIC ACID 3ALPHA TROPANYLAMIDE; ALPHA METHYLSEROTONIN; METHYSERGIDE; ONDANSETRON; PIRENPERONE; RECEPTOR SUBTYPE; SEROTONIN; SEROTONIN 1 ANTAGONIST; SEROTONIN 2 AGONIST; SEROTONIN 2 ANTAGONIST; SEROTONIN 4 AGONIST; SEROTONIN 4 ANTAGONIST; SEROTONIN 4 RECEPTOR;

ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; LYMPH FLOW; LYMPHATIC SYSTEM; MESENTERY LYMPH NODE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; RECEPTOR DENSITY; SHEEP; SMOOTH MUSCLE CONTRACTION; VASOCONSTRICTION;

EID: 0033747608     PISSN: 00262862     EISSN: None     Source Type: Journal    
DOI: 10.1006/mvre.2000.2275     Document Type: Article

References (27)

1. 4 receptor: A place in the sun
2. Further characterisation of the putative 5-HT receptor which mediates blockade of neurogenic plasma extravasation in rat dura mater
3. 4 receptors
4. Evidence for constriction of canine prenodal lymphatic vessels by vasoactive agents and carotid occlusion
5. 4 receptor positively coupled to adenylate-cyclase in brain
6. 4 receptor antagonist of the azabicycloalkyl benzimidazolone class - DAU-6285
7. Pharmacological analysis of 5-hydroxytryptamine receptors in isolated intracranial and extracranial vessels of cat and man
8. Modulation of lymphatic pumping by lymph borne factors after endotoxin administration in the sheep
9. 5-Hydroxytryptamine-induced relaxation of isolated mammalian smooth muscle
10. Heterogeniety of tracheobronchial lymphatic smooth muscle responses to histamine and 5-Hydroxytryptamine
11. Effects of histamine, 5-hydroxytryptamine and epinephrine on pulmonary hemodynamics with particular reference to arterial and venous segment resistances
12. Receptor mediated effects of serotonin and 5-methoxytryptamine on noradrenaline release in the rat vena cava and in the heart of the pithed rat
13. Effect of 5-hydroxytryptamine on spontaneous contractility of bovine mesenteric lymphatic vessels
14. 5-Hydroxytryptamine and neurotransmitter release in canine blood vessels: Inhibition by low and augmentation by high concentrations
15. The effect of transmural pressure on pumping activity in isolated bovine lymphatic vessels
16. A comparative study of function 5-HT4 receptors in human colon, rat oesophagus and rat ileum
17. Stimulation of cyclic AMP formation in the circular smooth muscle of human colon by activation of 5-HT4-like receptors
18. Characterization of the contraction to 5-HT in the canine colon longitudinal muscle
19. Intrinsic propulsive activity of the thoracic duct perfused in anaesthetised dogs
20. DAU-6285 - A novel antagonist at the putative 5-HT((4)) receptor
21. 4 receptor-mediated inhibition of sheep mesenteric lymphatic contractility
22. Effect of serotonin, epinephrine, histamine and hexamethonium on thoracic duct lymph
23. Contractile properties of lymphatics from the human lower leg
24. Excitatory and inhibitory effects of 5-hydroxytryptamine in mesenteric arteries of spontaneously hypertensive rats
25. Receptor mediation of the 5-hydroxytryptamine induced inflammation and nociception in rats
26. Characterisation of the 5-hydroxytryptamine receptor type involved in inhibition of spontaneous activity of isolated human colonic smooth muscle
27. Pharmacological characterization of the 5-hydroxytryptamine receptor mediating relaxation in the rat isolated ileum