Endothelin receptor blockade potentiates FasL-induced apoptosis in colon carcinoma cells via the protein kinase C-pathway

Journal of Cardiovascular Pharmacology

Volumn 36, Issue 5 SUPPL. 1, 2000, Pages

  Eberl, L P ^a   Egidy, G ^a   Pinet, F ^a   Juillerat Jeanneret, L ^a  

^a UNIVERSITY INSTITUTE OF PATHOLOGY   (Switzerland)

Author keywords

Apoptosis; Colon; Endothelin (ET); Fas ligand; Tumor

Indexed keywords

ANTINEOPLASTIC AGENT; BOSENTAN; ENDOTHELIN RECEPTOR; PROTEIN KINASE C;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; COLON CARCINOMA; DRUG MECHANISM; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0033743412     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-200036001-00063     Document Type: Article

References (9)

1. Production of endothelin in human cancer cell lines
2. Endothelin-1 as an autocrine/paracrine survival factor for endothelial cells
3. Endothelin attenuates apoptosis in human smooth muscle cells
4. The Fas death receptor
5. Fas and Fas ligand expression in tumor cells and in vascular smooth muscle cells of colon and renal carcinomas
6. Loco-regional Fas/APO-1 (CD95) ligand-mediated tumor cell killing in vivo
7. Modulation of human colon tumor-stromal interactions by the endothelin system
8. Programmed cell death induced by ceramide
9. Activation of protein kinase C attenuates early signals in Fas-mediated apoptosis