Physicochemical and crystallographic evidence for polymorphism of the racemic ethyl (2-chloromethyl-2,3-dihydro-5H-oxazolo [3,2-a]pyrimidin-5-one)-6-carboxylate

Journal of Pharmaceutical Sciences

Volumn 89, Issue 11, 2000, Pages 1496-1504

  Chaimbault, C ^a   Bosc, J J ^a   Leger, J M ^a   Negrier, P ^a   Capelle, F ^b   Jarry, C ^a  

^a UNIVERSITÉ DE BORDEAUX   (France)

^b CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BICYCLO COMPOUND; CARBOXYLIC ACID DERIVATIVE; ETHYL (2 CHLOROMETHYL 2,3 DIHYDRO 5H OXAZOLO[3,2 A]PYRIMIDIN 5 ONE) 6 CARBOXYLATE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL ANALYSIS; CHEMICAL MODIFICATION; CRYSTALLIZATION; CRYSTALLOGRAPHY; DIFFERENTIAL SCANNING CALORIMETRY; INFRARED SPECTROSCOPY; PHASE TRANSITION; RAMAN SPECTROMETRY; STEREOCHEMISTRY; TEMPERATURE SENSITIVITY; X RAY DIFFRACTION;

EID: 0033743307     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/1520-6017(200011)89:11<1496::AID-JPS12>3.0.CO;2-7     Document Type: Article

References (21)

1. On the pyrimidine synthesis from ethyl ethoxymethyl-enecyanoacetate and amidines
2. Reaction of 5-substituted 2-amino-2-oxazolines with ethoxycarbonyl isothiocyanate
3. Reaction of 5-substituted 2-amino-2-oxazolines with ethoxycarbonyl isocyanate: Access to 2,3,6,7-tetrahydro-4H-oxazolo [3,2-a]-1,3,5-triazin-2,4-diones
4. Reactions of 6-aminopyrimidines with bis-electrophiles: Manipulation of product composition with solvent and pyrimidine substitution variation
5. 'Chiral Pharmacology' and the regulation of new drugs
6. Characterization of racemic species of chiral drugs using thermal analysis, thermodynamic calculation, and structural studies
7. Relationship between physical properties and crystal structures of chiral drugs
8. X-ray structural studies and physicochemical characterization of (E)-6-(3,4-dimethoxyphenyl)-1-ethyl-4-mesitylimino-3-methyl-3,4-dihydro-2(1H) -pyrimidinone polymorphs
9. Untersuchungen uber einige Heterocyclen und deren Tautomeriefahigkeit
10. Crystals forms of piroxicam pivalate: Preparation and characterization of two polymorphs
11. Raman spectroscopy of LB films and monolayers at the air-water interface
12. Du signal aux phenomenes: Une approche pratique pour l'etablissement des diagrammes de phases par analyse thermique
13. Polymorphisme et chiralite de la N-phenyl N'- [1-{3-(1-phenyl-4-piperazino)propane-2-ol}]uree
14. 4
15. On enantiomorph-polarity estimation
16. Polymorphism of sulfathiazole
17. Demonstration of the terms enantiotropy and monotropy in polymorphism research exemplified by flurbiprofen