The secretory pore array hypothesis of transmitter release

Cell Biology International

Volumn 24, Issue 11, 2000, Pages 839-848

  Kriebel, M E ^a   Keller, B ^a   Fox, G Q ^b   Brown, O M ^a  

^a SUNY UPSTATE MEDICAL UNIVERSITY   (United States)

^b MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

Author keywords

MEPP; Neuromuscular junction; Quantum; Secretory pore; Sub MEPP; Transmitter

Indexed keywords

ANIMAL EXPERIMENT; DIAPHRAGM; ENDPLATE POTENTIAL; MEMBRANE ELECTROPHYSIOLOGY; MINIATURE ENDPLATE POTENTIAL; MOUSE; NEUROMUSCULAR SYNAPSE; NEUROTRANSMITTER RELEASE; NONHUMAN; REVIEW; SYNAPSE VESICLE;

EID: 0033739809     PISSN: 10656995     EISSN: None     Source Type: Journal    
DOI: 10.1006/cbir.2000.0633     Document Type: Review

References (85)

1. Ultrastructure of chemical synapses: A comparison between presynaptic membrane complexes of the motor end plate and the synaptic junction in the central nervous system
2. Exocytosis
3. Release of secretory products during transient vesicle secretory
4. The origin of Gaussian distributions of synaptic potentials
5. Quantal transmitter release at somatic motor-nerve terminals: Stochastic analysis of the subunit hypothesis
6. Sub-miniature end-plate potentials at untreated frog neuromuscular junctions
7. The relationship of transmitter release and storage to fine structure in a sympathetic ganglion
8. The fine structure of the neuromuscular junction of the frog
9. The end-plate potential in mammalian muscle
10. Currents through the secretory pore that forms during exocytosis of a secretory vesicle
11. Neostigmine increases the size of subunits composing the quantum of transmitter release at mouse neuromuscular junction
12. 2+-free solutions on the structure of the active zone
13. Freeze-fracture studies of frog neuromuscular junctions during intense release of neurotransmitter. II. Effects of electrical stimulation and high potassium
14. Effect of alphalatrotoxin on the frog neuromuscular junction at low temperature
15. Turnover of transmitter and synaptic vesicles at the frog neuromuscular junction
16. Vesicules synaptiques et poches au niveau des 'zones actives' de la jonction neuromusculaire
17. Quantal components of the end-plate potential
18. An inevitable gate for quantal acetylcholine release
19. Characteristics of spontaneous miniature and subminiature end-plate currents at the mouse neuromuscular junction
20. Subunit composition of the spontaneous miniature endplate currents at the mouse neuromuscular junction
21. Quantal acetylcholine release induced by mediatophore transfection
22. Spontaneous subthreshold actvity at motor nerve endings
23. Reversible effect of depolarization by K-propionate on sub-miniature endplate potential to bell-miniature endplate potential ratios, on miniature endplate potential frequencies and amplitudes, and on synaptic vesicle diameters and densities in frog neuromuscular junctions
24. The morphometric analysis of synaptic vesicle distributions
25. Dynamic responses of presynaptic membrane pools to electrical stimulation
26. Dynamic responses of presynaptic terminal membrane pools following KCl and sucrose stimulation
27. Multimodal distribution of MEPP amplitudes: The changing distribution with denervation, nerve stimulation, and high frequencies of spontaneous release
28. Evidence for recycling of synaptic vesicle membrane during transmitter release at the frog neuromuscular junction
29. Synaptic vesicle exocytosis captured by quick freezing and correlated with quantal transmitter release
30. Functional changes in frog neuromuscular junctions studied with freeze-fracture
31. Preservation of synaptic structure by rapid freezing
32. The release of acetylcholine: From a cellular towards a molecular mechanism
33. Exocytotic fusion: Total or transient?
34. G(i) regulation of secretory vesicle swelling examined by atomic force microscopy
35. The release of the neuromuscular transmitter and the present state of the hypothesis
36. The statistical nature of the acetycholine potential and its molecular components
37. Estimates of quantal content during 'chemical potentiation' of transmitter release
38. Ultrastructure of normal and stimulated motor endplates
39. 2+ saline
40. The neuromuscular junction
41. Sub-MEPPs, skew-MEPPs and the subunit hypothesis of quantal transmitter release at the neuromuscular junction
42. Effect of lanthanum ions on the amplitude distributions of miniature endplate potentials and on synaptic vesicles in frog neuromuscular junctions
43. Multimodal distribution of frog miniature endplate potentials in adult, denervated, and tadpole leg muscle
44. Spontaneous potentials and fine structure of identified frog denervated neuromuscular junctions
45. The unitary evoked potential at the frog nerve-muscle junction results from synchronous gating of fusion pores at docked vesicles
46. Porocytosis: Quantal secretion by an array of pores
47. ++ ionophore X-537A and a heat challenge on the distribution of mouse MEPP amplitude histograms
48. Spontaneous sub-miniature end-plate potentials in mouse diaphragm muscle: Evidence for synchronous release
49. Histograms of the unitary evoked potentials of the mouse diaphragm show multiple peaks
50. Hypertonic treatment reversibly increases the ratio of giant skew-miniature end plate potentials to bell-miniature endplate potentials
51. Description of the sub-miniature endplate potential distribution, determination of subunit size and number of subunits in the adult frog neuromuscular bell-miniature endplate potential
52. Effect of hypertonic saline on quantal size and synaptic vesicles in identified neuromuscular junction of the frog
53. Non-Poisson distribution in time of small- and large-mode miniature end-plate potentials
54. The number of transmitter molecules in a quantum: An estimate from iontophoretic application of acetylcholine at the neuromuscular synapse
55. A statistical model indicates that miniature end-plate potentials and unitary evoked end-plate potentials are composed of subunits
56. Low calcium-induced disruption of active zone structure and function at the frog neuromuscular junction
57. Changes in MEPP and EPP amplitude distributions in the mouse diaphragm during synapse formation and degeneration
58. Effects of stimulation and hemicholinium (HC-3) on the fine structure of nerve endings
59. Ultrastructure of botulinum type-A poisoned frog motor nerve terminals after enhanced quantal transmitter release caused by carbonylcyamide M-chlorophenylhyrazone
60. Synaptic vesicle depletion and recovery in cat sympathetic ganglia electrically stimulated in vivo
61. The binomial model in fluctuation analysis of quantal neurotransmitter release
62. Pre- and postfusion regulation of transmitter release
63. Ultrastructural changes with high activity and subsequent recovery at locust nerve motor nerve terminals. A stereological analysis
64. The fine structure of identified frog neuromuscular junctions in relation to synaptic activity
65. Quantitative ultrastructural analysis of hippocampal excitatory synapses
66. Surface dynamics in living acinar cells imaged by atomic force microscopy: Identification of plasma membrane structures involved in exocytosis
67. Compartmentalization of the submembrane calcium actvity during calcium influx and its significance in transmitter release
68. Supression by elevated calcium of black widow spider venom activity at frog neuromuscular junctions
69. Identification of a heparin sulphate containing proteoglycan as a specific core component of cholinergic synaptic vesicles from Torpedo marmorata
70. Proton NMR detection of acetylcholine status in synaptic vesicles
71. Are vesicles necessary for release of acetylcholine at cholinergic synapses?
72. Temporal coincidence between synaptic vesicle fusion and quantal secretion of acetylcholine
73. Statistical and graphical methods for testing the hypothesis that quanta are made up of subunits
74. Subunits in quantal transmission at the mouse neuromuscular junction: Test of peak intervals in amplitude distributions
75. Miniature endplate potentials induced by ammonium chloride, hypertonic shock and botulinum toxin
76. Characteristics of slow-miniature endplate currents show a subunit composition
77. Membrane events related to transmitter release in mouse motor nerve terminals captured by ultrarapid cryofixation
78. The effects of alphalatrotoxin on black widow spider venom on synaptosomal ultrastructure. A morphometric analysis correlating its effects on transmitter release
79. On the presynaptic nature of the quantal subunit
80. Quantum amplitude distributions point to junctional unity of the synaptic 'active zone'
81. The isolation of pure cholinergic synaptic vesicles from the electric organs of elasmobranch fish of the family Torpedinidae
82. The cholinergic system
83. Morphological and biochemical heterogeneity of cholinergic synaptic vesicles