The extracellular domain of BPAG2 has a loop structure in the carboxy terminal flexible tail in vivo

Journal of Investigative Dermatology

Volumn 115, Issue 5, 2000, Pages 889-892

  Nonaka, Shuko ^d   Ishiko, Akira ^d   Masunaga, Takuji ^d   Akiyama, Masashi ^a   Owaribe, Katsushi ^b   Shimizu, Hiroshi ^c   Nishikawa, Takeji ^d  

^a TEIKYO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NAGOYA UNIVERSITY   (Japan)

^c HOKKAIDO UNIVERSITY   (Japan)

^d NONE

Author keywords

Immunoelectron microscopy; Immunogold; Type XVII collagen

Indexed keywords

BULLOUS PEMPHIGOID ANTIGEN; MEMBRANE ANTIGEN; UNCLASSIFIED DRUG;

ANTIGEN DETECTION; ARTICLE; BASEMENT MEMBRANE; CARBOXY TERMINAL SEQUENCE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; HEMIDESMOSOME; HUMAN; HUMAN TISSUE; IMMUNOELECTRON MICROSCOPY; IMMUNOGOLD STAINING; PRIORITY JOURNAL; PROTEIN DOMAIN;

EID: 0033739631     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.2000.00136.x     Document Type: Article

References (21)

1. Cicatricial pemphigoid autoantibodies react with multiple sites on the BP180 extracellular domain
2. The major cicatricial pemphigoid antigen is a 180-kD protein that shows immunologic cross-reactivities with the bullous pemphigoid antigen
3. The localization of bullous pemphigoid antigen 180 (BP180) in hemidesmosomes is mediated by its cytoplasmic domain and seems to be regulated by the β4 integrin subunit
4. Isolation of a human epidermal cDNA corresponding to the 180-kD autoantigen recognized by bullous pemphigoid and herpes gestationis sera. Immunolocalization of this protein to the hernidesmosome
5. Cloning and primary structural analysis of the bullous pemphigoid autoantigen BP180
6. Demonstration of the molecular shape of BP180, a 180-kDa bullous pemphigoid antigen and its potential for trimer formation
7. Cleavage of BP180, a 180-kDa bullous pemphigoid antigen, yields a 120-kDa collagenous extracellular polypeptide
8. Human autoantibodies against the 230-kD bullous pemphigoid antigen (BPAG1) bind only to the intracellular domain of the hemidesmosome, whereas those against the 180-kD bullous pemphigoid antigen (BPAG2) bind along the plasma membrane of the hemidesmosome in normal human and swine skin
9. 97 kDa linear IgA bullous dermatosis antigen localizes in the lamina lucida between the NC16A and carboxyl terminal domains of the 180 kDa bullous pemphigoid antigen
10. 180-kD bullous pemphigoid antigen (BP180) is deficient in generalized atrophic benign epidermolysis bullosa
11. Genomic organization of collagenous domains and chromosomal assignment of human 180-kDa bullous pemphigoid antigen-2, a novel collagen of stratified squamous epithelium
12. Cloning of type XVII collagen. Complementary and genomic DNA sequences of mouse 180-kilodalton bullous pemphigoid antigen (BPAG2) predict an interrupted collagenous domain, a transmembrane segment, and unusual features in the 5'-end of the gene and the 3'-untranslated region of the mRNA
13. Localization of laminin-5 in the epidermal basement membrane
14. The extracellular domain of BPAG2 localizes to anchoring filaments and its carboxyl terminus extends to the lamina densa of normal human epidermal basement membrane
15. Mutations in the 180-kD bullous pemphigoid antigen (BPAG2), a hemidesmosomal transmembrane collagen (COL17A1), in generalized atrophic benign epidermolysis bullosa
16. Altered laminin 5 expression due to mutations in the gene encoding the α3 chain (LAMB3) in generalized atrophic benign epidermolysis bullosa
17. Herpes gestationis autoantibodies recognize a 180-kD human epidermal antigen
18. Isolation and characterization of hemidesmosomes from bovine corneal epithelial cells
19. Kalinin: An epithelium-specific basement membrane adhesion molecule that is a component of anchoring filaments
20. Demonstration of intra- and extracellular localization of bullous pemphigoid antigen using cryofixation and freeze substitution for postembedding immunoelectron microscopy
21. The use of silver-enhanced 1-nm gold probes for light and electron microscopic localization of intra- and extracellular antigens in skin