ACE inhibitors attenuate expression of renal transforming growth factor-β1 in humans

American Journal of Kidney Diseases

Volumn 36, Issue 5, 2000, Pages 894-902

  Shin, Gyu Tae ^a   Kim, Seung Jung ^a   Ma, Kyoung Ai ^a   Kim, Heung Soo ^a   Kim, Dohun ^a  

^a Ajou University School of Medicine   (South Korea)

Author keywords

Angiotensin converting enzyme (ACE) inhibitors; Glomerulonephritis; Transforming growth factor (TGF )

Indexed keywords

AMLODIPINE; BETA ACTIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; FOSINOPRIL; FUROSEMIDE; NIFEDIPINE; RAMIPRIL; TRANSFORMING GROWTH FACTOR BETA1;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; ENZYME INHIBITION; FEMALE; GENE EXPRESSION REGULATION; GLOMERULONEPHRITIS; HUMAN; IMMUNOGLOBULIN A NEPHROPATHY; MALE; PROTEIN EXPRESSION;

EID: 0033736454     PISSN: 02726386     EISSN: None     Source Type: Journal    
DOI: 10.1053/ajkd.2000.19078     Document Type: Article

References (53)

1. Therapeutic advantage of converting enzyme inhibitors in arresting progressive renal disease associated with systemic hypertension in the rat
2. In chronic nephropathies, prolonged ACE inhibition can induce remission: Dynamics of time-dependent changes in GFR
3. Angiotensin-converting enzyme inhibition and renal protection
4. Morphometric analysis of the actions of angiotensin II on renal arterioles and glomemli
5. Transforming growth factor-β in tissue fibrosis
6. Molecular insights into renal interstitial fibrosis
7. Sustained expression of TGF-β1 underlies development of progressive kidney fibrosis
8. Expression of TGF-β in human and experimental diabetic nephropathy
9. Quantification of glomemlar TGF-β1 mRNA in patients with diabetes mellitus
10. Glomerular TGF-β1 mRNA as a marker of glomerulosclerosis - Application in renal biopsies
11. Expression of TGF-β isoforms in human glomerular diseases
12. Renal TGF-β in HIV-associated kidney diseases
13. PDGF and TGF-β contribute to the natural course of human IgA glomerulonephritis
14. TGF-β protein and mRNA in glomeruli in normal and diseased human kidneys
15. Role of TGF-β1 in glomerulonephritis
16. Angiotensin in progressive renal diseases: Theory and practice
17. Immunoglobulin A nephropathy
18. Interactions of TGF-β and angiotensin II in renal fibrosis
19. Transforming growth factor-β1 and renal injury following nephrectomy in the rat: Role of the reninangiotensin system
20. Interaction of angiotensin II and TGF-β1 in the rat remnant kidney
21. Role of angiotensin II in the expression and regulation of TGF-β in obstructive nephropathy
22. Increased expression of TGF-β1 mRNA in the obstructed kidney of rats with unilateral ureteral ligation
23. The renoprotective properties of angiotensin-converting enzyme inhibitors in a chronic model of membranous nephropathy are solely due to the inhibition of angiotensin II: Evidence based on comparative studies with a receptor antagonist
24. Pharmacologic control of angiotensin II ameliorates renal disease while reducing renal TGF-β in experimental mesangioproliferative glomerulonephritis
25. Regulation of glomerular TGF-β expression in the contralateral kidney of two-kidney, one-clip hypertensive rats
26. Candesartan prevents the progression of glomerulosclerosis in genetic hypertensive rats
27. Cyclic stretching force selectively upregulates TGF-β isoforms in cultured mesangial cells
28. Regulation of extracellular matrix by mechanical stress in rat glomerular mesangial cells
29. TGF-β1 expression and phenotypic modulation in the kidney of hypertensive rats
30. Contribution of renal angiotensin II type I receptor to gene expressions in hypertension-induced renal injury
31. ACE inhibition reduces proteinuria, glomerular lesions and extracellular matrix production in a normotensive rat model of immune complex nephritis
32. Angiotensin II stimulates extracellular matrix protein synthesis through induction of transforming growth factor-β expression in rat glomerular mesangial cells
33. Angiotensin II-induced hypertrophy of cultured murine proximal tubular cells is mediated by endogenous TGF-β
34. Significance of mononuclear phagocytes in IgA nephropathy
35. Profiles of immunoregulatory cytokine production in vitro in patients with IgA nephropathy and their kindred
36. Detection of cytokine mRNA-expressing cells in peripheral blood of patients with IgA nephropathy using non-radioactive in situ hybridization
37. Increased mRNA encoding for transforming growth factor-beta in CD4+ cells from patients with IgA nephropathy
38. Detection of abnormal peripheral blood mononuclear cell cytokine networks in human IgA nephropathy
39. Cytosolic calcium changes induced by angiotensin II in human peripheral blood mononuclear cells are mediated via angiotensin II subtype 1 receptors
40. Angiotensin II type I receptor mRNA levels in human blood cells of patients with primary and secondary hypertension: Reference to renin profile
41. Activation of human peripheral monocytes by angiotensin II
42. Renal hemodynamics and plasma and kidney angiotensin II in established diabetes mellitus in rats: Effect of sodium and salt restriction
43. Urinary TGF-β excretion and renal production of TGF-β in rats with subtotal renal ablation: Effect of enalapril and nifedipine
44. Urinary TGF-β1 in membranous glomerulonephritis
45. Expression and secretion of type beta transforming growth factor by activated human macrophage
46. Neutralization of TGF-β by anti-TGF-β antibody attenuates kidney hypertrophy and the enhanced extracellular matrix gene expression in STZ-induced diabetic mice
47. Captopril prevents nephropathy in HIV-transgenic mice
48. Captopril-induced reduction of serum levels of transforming growth factor-β1 correlates with long-term renoprotection in insulin-dependent diabetic patients
49. Losartan decreases plasma levels of TGF-beta1 in transplant patients with chronic allograft nephropathy
50. TGF-β1 circulates in normal plasma and is unchanged in advanced metastatic breast cancer
51. The serum concentration of active TGF-β is severely depressed in advanced atherosclerosis
52. Elevated serum TGF-β1 level in primary lung cancer patients with finger clubbing
53. Elevation of bioactive TGF-β in serum from patients with chronic fatigue syndrome