The diphtheria toxin channel-forming T-domain translocates its own NH2-terminal region and the catalytic domain across planar phospholipid bilayers

International Journal of Medical Microbiology

Volumn 290, Issue 4-5, 2000, Pages 435-440

  Finkelstein, A ^a   Oh, K J ^c   Senzel, L ^a   Gordon, M ^a   Blaustein, R O ^b   Collier, R J ^c  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b BRANDEIS UNIVERSITY   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Channels; Diphtheria toxin; Planar bilayers; Translocation

Indexed keywords

EID: 0033735495     PISSN: 14384221     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1438-4221(00)80059-4     Document Type: Article

References (16)

1. Refined structure of monometic diphtheria toxin at 2.3 Å resolution
2. Membrane translocation and channel-forming activities of diphtheria toxin are blocked by replacing isoleucine 364 with lysine
3. The entry of diphtheria toxin into the mammalian cell cytoplasm: Evidence for lysosomal involvement
4. Diphtheria toxin at low pH depolarizes the membrane, increases the membrane conductance and induces a new type of ion channel in Vero cells
5. Replacement of negative by positive charges in the presumed membrane-inserted part of diphtheria toxin B fragment: Effect on membrane translocation and on formation of channels
6. Probing the structure of the diphtheria toxin channel: Reactivity in planar lipid bilayer membranes of cysteine-substituted mutant channels with methane thiosulfonate derivatives
7. Diphtheria toxin fragment forms large pores in phospholipid bilayer membranes
8. Structure-function relationship of the ion channel formed by diphtheria toxin in Vero cell membranes
9. Entry of ADP-ribosylating toxins into cells
10. Translocation of the catalytic domain of diphtheria toxin across planar phospholipid bilayers by its own T-domain
11. Major transmembrane movement associated with colicin Ia channel gating
12. Diphtheria toxin entry into cells is facilitated by low pH
13. 2-terminal region across planar bilayers
14. Mutational analysis of the helical hairpin region of diphtheria toxin transmembrane domain
15. Structure-function relationship in diphtheria toxin channels: Determining a minimal channel-forming domain
16. An intact transmembrane helix 9 is essential for the efficient delivery of the diphtheria toxin catalytic domain to the cytosol of target cells