The endothelin-A-receptor antagonist PD180988 (CI-1034) selectively reverses the pulmonary vasoconstrictor response to hypoxia in the lamb

Journal of Cardiovascular Pharmacology

Volumn 36, Issue 5 SUPPL. 1, 2000, Pages

  Coe, Y ^a   Haleen, S J ^a   Welch, K M ^a   Coceani, F ^a  

^a SCUOLA SUPERIORE SANT ANNA   (Italy)

Author keywords

Endothelin (ET); Hypoxia; Newborn; Pulmonary circulation; Treatment of pulmonary hypertension (PH)

Indexed keywords

CI 1034; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR ANTAGONIST; PD 180988; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BOLUS INJECTION; CARDIOPULMONARY HEMODYNAMICS; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; HEART MUSCLE CONTRACTILITY; HEART RIGHT ATRIUM; HYPOXIA; LAMB; LONG TERM CARE; LUNG CIRCULATION; LUNG VASOCONSTRICTION; NEWBORN; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PULMONARY HYPERTENSION; SYSTEMIC CIRCULATION;

ANIMALS; ANOXIA; ENDOTHELIN-1; PULMONARY CIRCULATION; RECEPTOR, ENDOTHELIN A; RECEPTORS, ENDOTHELIN; SHEEP; THIAZINES; VASOCONSTRICTION;

EID: 0033734715     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-200000006-00001     Document Type: Article

References (7)

1. BQ123, an ET(A)-receptor antagonist, attenuates hypoxic pulmonary hypertension in rats
2. Endothelin-A receptor antagonist prevents acute hypoxia-induced pulmonary hypertension in the rat
3. Involvement of endothelin-1 in hypoxic pulmonary vasoconstriction in the lamb
4. Evidence for endothelin involvement in the pulmonary vasoconstrictor response to systemic hypoxia in the isolated rat lung
5. Efficacy of CI-1020, an endothelin-A receptor antagonist, in hypoxic pulmonary hypertension
6. Enhanced ET(A)-receptor-mediated inhibition of K(v) channels in hypoxic hypertensive rat pulmonary artery myocytes
7. Synthesis of 1, 1-dioxo-2, 4-diphenyl-1, 2-dihydrobenzothiazines; discovery of PD180988, a potent ETA selective antagonist