Cyclodextrin enhances spermicidal effects of magainin-2-amide

Contraception

Volumn 62, Issue 2, 2000, Pages 99-103

  Wojcik, C ^a   Sawicki, W ^a   Marianowski, P ^b   Benchaib, M ^c   Czyba, J C ^c   Guerin, J F ^c  

^a MEDICAL UNIVERSITY OF WARSAW   (Poland)

^b MEDICAL UNIVERSITY OF WARSAW   (Poland)

^c EDOUARD HERRIOT HOSPITAL   (France)

Author keywords

Cyclodextrin; Human spermatozoa; Magainin 2 amide; Sperm motility; Sperm viability

Indexed keywords

CHOLESTEROL; MAGAININ 2 AMIDE; METHYL BETA CYCLODEXTRIN;

ARTICLE; CELL MEMBRANE; CELL VIABILITY; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE MICROSCOPY; MALE; SEMEN ANALYSIS; SPERMATOZOON CAPACITATION; SPERMATOZOON MIGRATION; SPERMATOZOON MOTILITY; VAGINA EPITHELIUM;

ANIMALS; ANTI-INFECTIVE AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; BETA-CYCLODEXTRINS; CELL MEMBRANE; CELLS, CULTURED; CHOLESTEROL; CONTRACEPTIVE AGENTS; CYCLODEXTRINS; HUMANS; MALE; SPERM CAPACITATION; SPERMATOZOA; XENOPUS LAEVIS; XENOPUS PROTEINS;

EID: 0033733345     PISSN: 00107824     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0010-7824(00)00143-8     Document Type: Article

References (22)

1. Structure-activity studies on magainins and other host defense peptides
2. Magainins, a class of antimicrobial peptides from Xenopus skin; isolation, characterization of two active forms, and partial cDNA sequence of a precursor
3. Molecular basis for prokaryotic specificity of magainin-induced lysis
4. Magainins affect respiratory control, membrane potential and motility of hamster spermatozoa
5. Studies on the in vitro spermicidal activity of synthetic magainins
6. Spermicidal activity of Magainins; in vitro and in vivo studies
7. Antibiotic magainins exert cytolytic activity against transformed cell lines through channel formation
8. Experimental local therapy of human melanoma with lytic magainin peptides
9. Contraceptive potential of peptide antibiotics
10. Cyclodextrin removes cholesterol from mouse sperm and induces capacitation in a protein-free medium
11. Regulation of human sperm capacitation by a cholesterol efflux-stimulated signal transduction pathway leading to protein kinase A-mediated up-regulation of protein tyrosine phosphorylation
12. Effect of methyl-beta-cyclodextrin on the acrosomal responsiveness of human sperm
13. Comparison of techniques for selection of motile spermatozoa
14. Fluorometric assessments of mitochondrial function and viability in cryopreserved bovine spermatozoa
15. Death-effector filaments; novel cytoplasmic structures that recruit caspases and trigger apoptosis
16. Mechanisms of drug release from cyclodextrin complexes
17. Efficacy, safety and mechanism of cyclodextrins as absorption enhancers in nasal delivery of peptide and protein drugs
18. Beta cyclodextrins enhance adenoviral-mediated gene delivery to the intestine
19. Transdermal permeation modulation by cyclodextrins; a mechanistic study
20. Cholesterol depletion of caveolae causes hyperactivation of extracellular signal-related kinase (ERK)
21. Effects of cholesterol depletion by cyclodextrin on the sphingolipid microdomains of the plasma membrane