Risks associated with peri-operative use of alpha2-adrenoceptor agonists

Bailliere's Best Practice and Research in Clinical Anaesthesiology

Volumn 14, Issue 2, 2000, Pages 347-368

  Quintin, L ^a,b   Ghignone, M ^c  

^a HÔPITAL NORD   (France)

^b UNIVERSITÉ LYON 1   (France)

^c Pinecrest Rehabilitation Hospital   (United States)

Author keywords

Anaesthesia; Bradycardia; Clonidine; Coronary artery disease; Critical care; Dexmedetomidine; Emergence; Hypertension; Hypotension; Hypovolaemia; Lower body negative pressure; Mivazerol; Surgery; 2 agonists

Indexed keywords

ADRENERGIC RECEPTOR BLOCKING AGENT; ALFENTANIL; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; ATROPINE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CHOLINERGIC RECEPTOR BLOCKING AGENT; CLONIDINE; DEXMEDETOMIDINE; DILTIAZEM; EPHEDRINE; FENTANYL; HEXAMETHONIUM; HYPERTENSIVE AGENT; ISOFLURANE; ISOPRENALINE; KETANSERIN; MIDAZOLAM; MIVAZEROL; MORPHINE; NEUROLEPTIC AGENT; OPIATE DERIVATIVE; PHENOXYBENZAMINE; PHENYLEPHRINE; PROPOFOL; PROPRANOLOL; REMIFENTANIL; RESERPINE; UNINDEXED DRUG; VASOACTIVE AGENT;

ANESTHESIA; ANESTHESIA INDUCTION; BRADYCARDIA; CLINICAL TRIAL; DOSE RESPONSE; DRUG ABSORPTION; DRUG ANTAGONISM; DRUG EFFECT; DRUG INHIBITION; DRUG POTENTIATION; DRUG TOLERANCE; DRUG USE; FORWARD HEART FAILURE; HUMAN; HYPERTENSION; HYPOTENSION; HYPOVOLEMIA; INTENSIVE CARE; ISCHEMIC HEART DISEASE; META ANALYSIS; NONHUMAN; PERIOPERATIVE PERIOD; PRIORITY JOURNAL; REVIEW; SEDATION; SURGICAL RISK;

EID: 0033731903     PISSN: 15216896     EISSN: None     Source Type: Journal    
DOI: 10.1053/bean.2000.0088     Document Type: Article

References (109)

1. Effects of clonidine on narcotic requirements and hemodynamic response during induction of fetanyl anesthesia and endotracheal intubation
2. Anesthesia and hypertension: The effect of clonidine on perioperative hemodynamics and isoflurane requirements
3. Anesthesia for ophthalmic surgery in the elderly: The effects of clonidine on intraocular pressure, perioperative hemodynamics and anesthetic requirements
4. Effect of clonidine on myocardial ischemia: A double-blind pilot trial
5. Clonidine improves perioperative myocardial ischemia, reduces anesthetic requirement, and alters hemodynamic parameters in patients undergoing coronary artery bypass surgery
6. Small oral dose of clonidine reduces the incidence of intraoperative myocardial ischemia in patients having vascular surgery
7. Perioerative sympatholysis: Beneficial effect of the alpha-2 adrenoceptor agonist mivazerol on hemodynamic stability and myocardial ischemia
8. Effect of mivazerol on perioperative cardiac complications during non-cardiac surgery in patients with coronary disease
9. Preoperative and postoperative use of clonidine with neuroleptanesthesia
10. Perioperative clonidine withdrawal syndrome
11. Nervous control of blood vessels
12. Effect of clonidine and gamma-aminobutyric acid in the discharges of medullo-spinal sympathoexcitatory neurons in the rat
13. Susceptibility of spontaneous sympathetic outflow and sympathetic reflexes to depression by clonidine
14. Clonidine reduces the ADH response and the dose requirement during nitroprusside induced hypotension
15. Intrathecal clonidine and the response to hemorrhage
16. Effects of alpha adrenoceptor antagonists and clonidine on the hemodynamic response to acute hypovolemia in conscious rabbits
17. Comparison of the effects of clonidine on pre- and postsynaptic adrenoceptors in the rabbit pulmonary artery
18. Inhibition of sympathetic transmission in rat heart by clonidine: The roles of stimulation frequency, endogenous feedback and noradrenaline reuptake
19. Mechanism of the antihypertensive action of clonidine on the pressor response to physostigmine
20. Activation of the central pathway of the baroreceptor reflex, a possible mechanism of the hypotensive action of clonidine
21. The effect of clonidine on the fastigial pressor response in dogs
22. The effect of clonidine on adrenergic nerve function in vagotomized and nonvagotomized animals
23. Activation of brain noradrenergic neurons during recovery from halothane anesthesia : Persistence of phasic activation after clonidine
24. Clonidine modulates locus coeruleus metabolic hyperactivity induced by stress in behaving rats
25. Effects of sympathetic blocking substances on the diving reflex of ducks
26. Interaction of alpha-methyldopa with autonomic reflex tachycardia in man
27. The effects of increasing plasma concentrations of dexmedetomidine in humans
28. Circulatory effects at rest and exercise of clonidine, an imidazoline derivative with hypotensive properties
29. Reflex vasoconstrictor responses to cardiopulmonary baroreceptor unloading, head-up tilt and cold pressor testing in elderly mild-to moderate hypertensives: Effect of clonidine
30. The efficacy of a transdermal formulation of clonidine in mild to moderate hypertension and its effects on the arterial and venous vasculature of the forearm
31. Effect of clonidine on sympathetic nervous activity in patients with essential hypertension
32. Effects of oral clonidine on baroreflex function in patients with essential hypertension
33. Antihypertensive effects of clonidine in tetraplegic subjects devoid of central sympathetic control
34. Spontaneous cardiac baroreflex in humans: Comparison with drug-induced responses
35. Effect of intravenous dexmedetomidine in humans. II. Hemodynamic changes
36. Intramuscular dexmedetomidine as premedication for general anesthesia. A comparative multicenter study
37. Clonidine reduces blood pressure and heart rate oscillations in hypertensive patients
38. Risk factors for severe bradycardia during oral clonidine therapy for hypertension
39. Sedative, amnesic and analgesic properties of small-dose dexmedetomidine infusions
40. Direct arterial pressure recording in unrestricted man
41. Sleep and blood pressure
42. Beta-adrenergic blocking treatment and 24-hour baroreflex sensitivity in essential hypertensive patients
43. Dose-response effects of intravenous clonidine on stress response during induction of anesthesia in coronary artery bypass graft
44. Pharmacology of clonidine
45. Reduced narcotic requirement by clonidine with improved hemodynamic and adrenergic stability in patients undergoing coronary bypass surgery
46. Haemodynamic changes and oxygen uptake during crossclamping of the thoracic aorta in dexmedetomidine pretreated dogs
47. Clonidine prevents the sympathetic initiation and aggravation of post-stenotic myocardial ischemia
48. Oral clonidine premedication decreases energy expenditure in human volunteers
49. Oxygen uptake and mixed venous oxygen saturation during aortic surgery and the first three postoperative hours
50. Relationship between oxygen uptake and mixed venous oxygen saturation in the immediate postoperative period
51. Clonidine prevention of myocardial ischemia during cardiac surgery: Will this change outcome?
52. Oxygen uptake after major abdominal surgery: Effect of clonidine
53. Clonidine and ketanserin both are effective treatment for postanesthetic shivering
54. The effect of clonidine on human isolated smooth muscle
55. Effects of clonidine on aortic diameter and aortic baroreceptor activity
56. Neurogenic and humoral factors maintaining arterial pressure in conscious dogs
57. Centrally induced reduction in sympathetic tone: A postsynaptic alpha-adrenoceptor-stimulating action of imidazolines
58. Studies of anaesthesia in relation to hypertension. I. Cardiovascular responses of treated and untreated patients
59. Dexmedetomidine as an anesthetic adjunct in coronary bypass grafting
60. The baroreceptor input to cardiac vagal motoneurones
61. The action of clonidine on the baroreflex control of heart rate in conscious animals and man and on single aortic baroreceptor discharge in the rabbit
62. Cardiac baroreflex during the postoperative period in patients with hypertension: Effect of clonidine
63. Epidemiology of the adverse hemodynamic events occurring during 'clonidine anesthesia': A prospective open trial of intraoperative intravenous clonidine
64. Oral clonidine blunts the heart rate response to intravenous atropine in humans
65. Clonidine for aortic surgery in hypertensive patients: A double blind controlled randomized study
66. Enhancement of pressor response to intravenous phenylephrine following oral clonidine medication in awake and anaesthetized patients
67. Oral clonidine preanesthetic medication augments the pressor responses to intravenous ephedrine in awake or anesthetized patients
68. The effects of clonidine on sensitivity to phenylephrine and nitroprusside in patients with essential hypertension recovering from surgery
69. The effects of intraoperative intravenous clonidine on fluid requirements, hemodynamic variables, and support during liver transplantation: A prospective, randomized study
70. Pharmacology of the autonomic nervous system
71. Preserved sympathetic response to hypotension despite perioperative alpha-2 agonist administration
72. Clonidine and cardiac surgery: Hemodynamic and metabolic effects, myocardial ischemia and recovery
73. Reflex bradycardia during surgery
74. Facilitation of the Bezold-Jarisch reflex by central stimulation of alpha-2 adrenoceptors in dogs
75. Effect of perioperative dexmedetomidine infusion in patients undergoing vascular surgery
76. Changes in cardiac function after effective treatment of hypertensive emergencies with i.v. clonidine
77. Clinical efficacy of oral-transdermal clonidine combination during the perioperative period
78. Premedication with oral and transdermal clonidine provides safe and efficacious postoperative sympatholysis
79. Epidural clonidine used as the sole analgesic agent during and after abdominal surgery
80. Clonidine premedication for coronary artery bypass grafting under high-dose alfentanil anesthesia: Intraoperative and postoperative hemodynamic study
81. Blood pressure response and plasma fentanyl concentrations during high- and very high-dose fentanyl anesthesia for coronary artery surgery
82. Additive effects of oral clonidine and fentanyl on isoflurane-induced hypotension: A double blind study
83. Clonidine does not prevent myocardial ischemia during non-cardiac surgery
84. Oral clonidine premedication for elderly patients undergoing intraocular surgery
85. Preanesthetic medication with clonidine
86. Cardiovascular effects of intravenous clonidine
87. Clonidine in congestive heart failure: A vasodilator with negative inotropic effects
88. Short-term effects of intravenous clonidine in congestive heart failure
89. Suppressing sympathetic activation in congestive heart failure: A new therapeutic strategy
90. The role of clonidine in hypertensive heart disease. Influence on myocardial contractility and left ventricular afterload
91. The effect of clonidine on myocardial contractility
92. Beta-blockers in heart failure: The 'new wave' of clinical trials
93. Changes in cerebral hemodynamics after a single dose of clonidine in severely head-injured patients
94. Dexmedetomidine efficacy for ICU postoperative sedation
95. Preliminary UK experience of dexmedetomidine, a novel agent for postoperative sedation in the intensive care unit
96. Effects of a single pre-operative dexmedetomidine dose on isoflurane requirements and perioperative hemodynamic stability
97. Effect of clonidine on the circulation and vasoactive hormones after aortic surgery
98. Postoperative analgesia by intravenous clonidine
99. Diuretic effect of clonidine during isoflurane-nitrous oxide and oxygen anesthesia
100. Improved hemodynamic and renal function with clonidine in coronary artery bypass grafting
101. Preoperative alpha-2 adrenergic receptor agonists prevent the deterioration of renal function after cardiac surgery: Results of a randomized, controlled trial
102. Clonidine does not delay recovery from anaesthesia
103. A dose-response study of orally administered clonidine as premedication in the elderly: Evaluating hemodynamic safety
104. Technique actuelle de l'hibernation artificielle
105. Clonidine as a sedative adjunct in intensive care
106. Dexmedetomidine
107. The effects of dexmedetomidine in patients in the intensive care setting
108. Safety of alpha-2 agonists?