Pharmacological effects of milnacipran, a new antidepressant, given repeatedly on the α1-adrenergic and serotonergic 5-HT(2A) systems

Journal of Neural Transmission

Volumn 107, Issue 11, 2000, Pages 1345-1359

  Maj, J ^a   Rogoz Z ^a   Dlaboga, D ^a   Dziedzicka Wasylewska, M ^a  

^a INSTITUTE OF PHARMACOLOGY   (Poland)

Author keywords

Adaptive changes in noradrenaline and serotonin systems; Milnacipran; Repeated treatment

Indexed keywords

4 IODO 2,5 DIMETHOXYAMPHETAMINE; 5 HYDROXYTRYPTOPHAN; ANTIDEPRESSANT AGENT; CLONIDINE; METHOXAMINE; MILNACIPRAN; NORADRENALIN UPTAKE INHIBITOR; PHENYLEPHRINE; PRAZOSIN; SEROTONIN UPTAKE INHIBITOR; TRITIUM;

ADRENERGIC SYSTEM; AGGRESSION; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; DEPRESSION; DRUG EFFECT; DRUG RECEPTOR BINDING; HYPERACTIVITY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PSYCHOPHARMACOLOGY; RAT; SEROTONINERGIC SYSTEM;

5-HYDROXYTRYPTOPHAN; ADRENERGIC ALPHA-AGONISTS; ADRENERGIC UPTAKE INHIBITORS; AGGRESSION; AMPHETAMINES; ANIMALS; ANTIDEPRESSIVE AGENTS; BEHAVIOR, ANIMAL; CEREBRAL CORTEX; CLONIDINE; CYCLOPROPANES; DYSKINESIA, DRUG-INDUCED; EXPLORATORY BEHAVIOR; MALE; METHOXAMINE; RATS; RATS, WISTAR; RECEPTORS, ADRENERGIC, ALPHA; RECEPTORS, SEROTONIN; SEROTONIN AGONISTS; SEROTONIN UPTAKE INHIBITORS;

EID: 0033728989     PISSN: 03009564     EISSN: None     Source Type: Journal    
DOI: 10.1007/s007020070022     Document Type: Article

References (46)

1. Controlled comparison of two doses of milnacipran (F 2207) and amitriptyline in major depressive inpatients
2. Controlled comparison of milnacipran (F 2207) 200 mg and amitriptyline in endogenous depressive inpatients
3. Effects of prolonged administration of milnacipran, a new antidepressant, on receptors and monoamine uptake in the brain of the rat
4. Effect of milnacipran on the serotonin and noradrenaline reuptake processes: Fundamental and clinical implications
5. Central and peripheral changes in α-adrenoceptors in the rat after chronic tricyclic antidepressants
6. Therapeutic contribution of milnacipran and clomipramine during a 3-month treatment results of a comparative study
7. A method for assessing the effects of drugs on the central actions of 5-hydroxytryptamine
8. Enhanced serotonin receptor activity after chronic treatment with imipramine or amitriptyline
9. 1 receptor characteristic in frontal cortex and 5-HT receptor-mediated head-twitch behaviour following antidepressant treatment to mice
10. 2 antagonist pirenperone
11. Biochemical effects and drug levels in rats after long-term treatments with the specific 5HT uptake inhibitor, citalopram
12. Chemistry and pharmacology of compounds related to 4-(4-hydroxy-4-phenyl-piperidino)-butyrophenone, part IV. Influence of haloperidol (r 1625) and of chloropromazine on the behaviour of rats in unfamiliar 'open field' situation
13. Comparative studies with milnacipran and tricyclic antidepressants in the treatment of patients with major depression: A summary of clinical trial results
14. 1-adrenoceptor agonist affinity in the rat brain
15. 2 receptors in the rat brain
16. Locomotor activity and motor disturbances induced by the competitive antagonist CGP 37849
17. Long-term efficacy and safety of milnacipran compared to clomipramine in patients with major depression
18. 2 receptor binding sites
19. Behavioural effects of indole and piperazine type serotonin receptor agonist
20. 1-adrenergic, dopamine and serotonin systems
21. Chronic treatment with antidepressants: Potentiation of clonidine-induced aggresion in mice via noradrenergic mechanism
22. 1-adrenoceptors in the rat cortex
23. Antidepressant and drugs given repeatedly increase the behavioural effects of methoxamine
24. Oxaprotiline enantiomers given repeatedly and brain-adrenoceptors
25. The effects of paroxetine given repeatedly on the 5-HT receptor subpopulations in the rat brain
26. 1-adrenergic, dopaminergic and serotonergic receptors in rat brain
27. Cholinergic-dopaminergic interactions and the mechanisms of action of antidepressant
28. Effects of clonidine on growth hormone release in psychiatric patients and controls
29. 1-adrenoceptors
30. 1-adrenoceptor agonist after treatment with antidepressant drugs is not conditioned by β-down-regulation
31. Efficacy and tolerability of milnacipran: An overview
32. Biochemical profile of midalcipran (F 2207), 1-phenyl-diethy-aminocarbonyl-2-aminomethylcyclopropane (Z) hydrochloride, a potential fourth generation antidepressant drug
33. Lack of effect of repeated administration of milnacipran, a double noradrenaline and serotonin reuptake inhibitor, on the β-adrenoceptor-linked adenylate cyclase system in the rat cerebral cortex
34. 3H-prazosin binding to different rat brain structures
35. Potentiating effect of lithium chloride on aggressive behaviour induced in mice by nialamide plus L-DOPA and clonidine
36. Pharmacokinetics of milnacipran in comparision with other antidepressants
37. Study on the influence of milnacipran on the activity of cytochrome P450 isoenzimes in healthy volunteers
38. Pharmacodynamics of milnacipran in young and eldlery volunteers
39. Pharmacological profile of milnacipran, a new antidepressant, given acutely
40. An early clinical trial of milnacipran, a potential fourth generation antidepressant
41. Milnacipran. A review of its use in depression
42. A double-blind six months comparative study of milnacipran and clomipramine in major depressive disorder
43. Psychopharmacology of midalcipran, 1-phenyl-1-diethyl-aminocarbonyl-2-aminomethyl-cyclo-propane hydrochloride (F 2207), a new potential antidepressant
44. 1-adrenoceptor binding sites in rat brain
45. 3H-prazosin binding sites in the rat