Pharmacokinetics and comparative effects of telithromycin (HMR 3647) and clarithromycin on the oropharyngeal and intestinal microflora

Journal of Antimicrobial Chemotherapy

Volumn 46, Issue 5, 2000, Pages 741-749

  Edlund, Charlotta ^a,b   Alván, Gunnar ^a   Barkholt, Lisbeth ^a   Vacheron, Françoise ^c   Nord, Carl Erik ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b SÖDERTÖRN UNIVERSITY   (Sweden)

^c SANOFI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CLARITHROMYCIN; PLACEBO; TELITHROMYCIN;

ABDOMINAL PAIN; ADULT; ALPHA HEMOLYTIC STREPTOCOCCUS; ANTIBIOTIC RESISTANCE; AREA UNDER THE CURVE; ARTICLE; BACTEROIDES; CLINICAL TRIAL; CLOSTRIDIUM DIFFICILE; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG SALIVA LEVEL; ENTEROBACTERIACEAE; ENTEROCOCCUS; FECES; FEMALE; FUNGUS GROWTH; HUMAN; HUMAN EXPERIMENT; INTESTINE FLORA; MALE; MICROFLORA; MINIMUM INHIBITORY CONCENTRATION; NORMAL HUMAN; OROPHARYNX; PHARYNGITIS; RANDOMIZED CONTROLLED TRIAL; TASTE DISORDER; YEAST;

EID: 0033728021     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/46.5.741     Document Type: Article

References (21)

1. Ketolides: Semisynthetic 14-membered ring macrolides
2. Structure-activity relationship of the ketolide telitromycin
3. The in-vitro activity of HMR 3647, a new ketolide antimicrobial agent
4. In vitro activities of two ketolides, HMR 3647 and HMR 3004, against Gram-positive bacteria
5. Comparative in-vitro activity of ketolide HMR 3647 and four macrolides against Gram-positive cocci of known erythromycin susceptibility status
6. In vitro activity of HMR 3647 against anaerobic bacteria
7. Colonization of the oropharynx with pathogenic microorganisms - A potential risk factor for infection in compromised patients
8. Diagnosis and treatment of Clostridium difficile colitis
9. Inactivation of antibiotics and the dissemination of resistance genes
10. Comparative effects of clarithromycin and erythromycin on the normal intestinal microflora
11. Comparative effects of omeprazole, amoxycillin plus metronidazole versus omeprazole, clarithromycin plus metronidazole on the oral, gastric and intestinal microflora in Helicobacter pylori infected patients
12. Comparative effects of moxifloxacin and clarithromycin on the normal intestinal microflora
13. Effect of phenoxymethyl-penicillin and clindamycin on the oral, throat and faecal microflora of man
14. Ecological impact of antimicrobial agents on human intestinal microflora
15. Adverse effects of macrolide antibacterials
16. Activity of HMR 3647 compared to those of five agents against Haemophilus influenzae and Moraxella catarrhalis by MIC determination and time-kill assay
17. Evidence suggesting importance of role of interbacterial inhibition in maintaining balance of normal flora
18. Bacterial interference in upper respiratory tract infections