Inhibition of vascular smooth muscle cell adhesion and migration by c7E3 Fab (abciximab): A possible mechanism for influencing restenosis

Cardiovascular Research

Volumn 48, Issue 3, 2000, Pages 464-472

  Baron, J H ^a   Moiseeva, E P ^a   De Bono, D P ^a   Abrams, K R ^a   Gershlick, A H ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

Extracellular matrix; Monoclonal antibodies; Receptors; Restenosis; Smooth muscle

Indexed keywords

ABCIXIMAB; INTEGRIN; OSTEOPONTIN; SCLEROPROTEIN; VITRONECTIN;

ARTICLE; CELL ADHESION; CELL MIGRATION; CONGENITAL HEART DISEASE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DETERMINATION; PROTEIN EXPRESSION; QUANTITATIVE ASSAY; VASCULAR SMOOTH MUSCLE;

ANALYSIS OF VARIANCE; ANTIBODIES, MONOCLONAL; CELL ADHESION; CELL MOVEMENT; CELLS, CULTURED; CORONARY DISEASE; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; IMMUNOGLOBULIN G; MUSCLE, SMOOTH, VASCULAR; OSTEOPONTIN; PLATELET AGGREGATION INHIBITORS; PLATELET-DERIVED GROWTH FACTOR; RECEPTORS, VITRONECTIN; RECURRENCE; SAPHENOUS VEIN; SIALOGLYCOPROTEINS; VITRONECTIN;

EID: 0033715784     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(00)00201-7     Document Type: Article

References (38)

1. Use of a monoclonal antibody directed against the platelet glycoprotein IIb/IIIa receptor in high-risk coronary angioplasty
2. Inhibition of dog platelet function by in vivo infusion of F(ab')2 fragments of a monoclonal antibody to the platelet glycoprotein IIb/IIIa receptor
3. Safety and antiplatelet efficacy of murine monoclonal antibody 7E3 Fab directed against glycoprotein IIb/IIIa in patients undergoing selective coronary angioplasty
4. 3 integrins
5. Smooth muscle migration in atherosclerosis and restenosis
6. Integrins and vascular extracellular matrix assembly
7. 3 integrins are upregulated after vascular injury and modulate thrombospondin- and thrombin-induced proliferation of cultured smooth muscle cells
8. 1-integrins dominate integrin-matrix interactions involved in postinjury smooth muscle cell migration
9. 3 integrins have different roles in the adhesion and migration of vascular smooth muscle cells on extracellular matrix
10. 3 integrin
11. Stimulation of migration of human aortic smooth muscle cells by vitronectin: Implications for atherosclerosis
12. 3 in smooth muscle cell migration to osteopontin in vitro
13. 3 integrin complex is reversed by activated calcium/calmodulin-dependent protein kinase II
14. 3 integrin with a small peptide agonist GpenGRGDSPCA
15. Inhibition of integrin function by a cyclic RGD-containing peptide prevents neointima formation
16. 3 and osteopontin expression during neointima formation
17. 3 integrin in the development of coronary artery restenosis after angioplasty
18. Vitronectin expression and interaction with receptors in smooth muscle cells from human atheromatous plaque
19. Platelet-derived growth factor promotes smooth muscle migration and intimal thickening in a rat model of balloon angioplasty
20. Galectin-1 modulates attachment, spreading and migration of cultured vascular smooth muscle cells via interactions with cellular receptors and components of extracellular matrix
21. A comparison of balloon-expandable-stent implantation with balloon angioplasty in patients with coronary artery disease
22. Management of restenosis within the Palmaz-Schatz stent (the US multicenter experience)
23. Light microscopic immunolocation of thrombospondin in human tissues
24. Preclinical development of c7E3 Fab; a mouse/human chimeric monoclonal antibody fragment that inhibits platelet function by blockade of GPIIb/IIIa receptors with observations on the immunogenicity of c7E3 Fab in humans
25. 1 integrin receptors by human vascular smooth muscle cells. α2β1 Integrin is required for chemotaxis across type 1 collagen-coated membranes
26. 3-integrin expression in normal and atherosclerotic artery
27. The role of integrins in saphenous vein vascular smooth muscle migration
28. The urokinase receptor is a major vitronectin-binding protein on endothelial cells
29. The serpin PAI-1 inhibits cell migration by blocking integrin αvβ3 binding to vitronectin
30. 5-directed cell migration
31. Plasminogen activator inhibitor-1 represses integrin- and vitronectin-mediated migration independently of its function as an inhibitor of plasminogen activation
32. Reduced intimal thickening following alpha v beta 3 blockade is associated with smooth muscle cell apoptosis
33. Long term protection from myocardial ischaemic events in a randomised trial of brief integrin beta 3 blockade with percutaneous coronary intervention
34. Six-month angiographic outcome with abciximab and stents: The EPISTENT angiographic substudy
35. Acute platelet inhibition with abciximab does not reduce in-stent restenosis
36. Abciximab reduces vascular lesion formation in non human primates
37. In vitro evaluation of c7E3 Fab (Reo Pro(TM)) eluting polymer-coated coronary stents