Effects of mibefradil and nifedipine on arteriolar myogenic responsiveness and intracellular Ca2+

British Journal of Pharmacology

Volumn 131, Issue 6, 2000, Pages 1065-1072

  Potocnik, Simon J ^a   Murphy, Timothy V ^a   Kotecha, Neela ^b   Hill, Michael A ^a  

^a RMIT UNIVERSITY   (Australia)

^b MONASH UNIVERSITY   (Australia)

Author keywords

Arterioles; Membrane potential; Myogenic response; Myogenic tone; Smooth muscle

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; CALCIUM ION; MIBEFRADIL; NIFEDIPINE; POTASSIUM CHLORIDE;

ANIMAL TISSUE; ARTERY BLOOD FLOW; ARTERY CONSTRICTION; ARTERY TONE; ARTICLE; CALCIUM CELL LEVEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CREMASTER MUSCLE; DEPOLARIZATION; MALE; MUSCLE FIBER MEMBRANE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE CONTRACTILITY;

EID: 0033711474     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703650     Document Type: Article

References (36)

1. Classes of calcium channels in vertebrate cells
2. Endothelium-derived hyperpolarizing factors and vascular cytochrome P450 metabolites of arachidonic acid in the regulation of tone
3. +
4. Discovery and main pharmacological properties of mibefradil (Ro 40-5967), the first selective T-type calcium channel blocker
5. Signaling mechanisms underlying the vascular myogenic response
6. Stretch-activated single-channel and whole-cell currents in vascular smooth muscle cells
7. Stretch-induced increases in intracellular calcium in isolated vascular smooth muscle cells
8. Methods for isolation, cannulation, and in vitro study of single microvessels
9. Contribution of two types of calcium channels to membrane conductance of single myocytes from guinea-pig coronary artery
10. Pressure-dependent membrane depolarization in cat middle cerebral artery
11. 2+ antagonist, Ro 40-5967
12. Calcium entry and myogenic phenomena in skeletal muscle arterioles
13. Evidence for protein kinase C involvement in arteriolar myogenic reactivity
14. Arteriolar arcades and pressure distribution in cremaster muscle microcirculation
15. 2+(i) following acute pressure increases are not obligatory for myogenic constriction
16. 2- sensitivity of isolated arterioles from the hamster cheek pouch
17. 2+] in cerebral arteries of rat by membrane potential and intravascular pressure
18. 2+ influx
19. Stretch-dependent calcium uptake associated with myogenic tone in rabbit facial vein
20. Inhibition of myogenic tone by mibefradil in rat cerebral arteries
21. Evidence for two distinct calcium channels in rat vascular smooth muscle cells in short-term primary culture
22. Myogenic contraction by modulation of voltage-dependent calcium currents in isolated rat cerebral arteries
23. Calcium measurement in isolated arterioles during myogenic and agonist stimulation
24. Myogenic constriction of human coronary arterioles
25. 2+ channels by RO 40-5967
26. Mibefradil, a T-type and L-type calcium channel blocker, limits infarct size through a glibenclamide-sensitive mechanism
27. Chloride channel blockers inhibit myogenic tone in rat cerebral arteries
28. Calcium channels, potassium channels and voltage dependence of arterial smooth muscle tone
29. - channels in macrovascular endothelial cells
30. Protein kinase C modulates basal myogenic tone in resistance arteries from the cerebral circulation
31. Metabolic interactions between mibefradil and HMG-CoA reductase inhibitors: An in vitro investigation with human liver preparations
32. Human vascular to cardiac tissue selectivity of L- and T-type calcium channel antagonists
33. Myogenic tone in isolated perfused resistance vessels from rats
34. Voltage-operated calcium channels are essential for the myogenic responsiveness of cannulated rat mesenteric small arteries
35. 2+](i) in myogenic reactivity and arteriolar tone
36. 2+](i) during myogenic and agonist-induced contraction